Convenient multigram synthesis of (R)-homopipecolic acid methyl ester

被引：6

作者：

Breuning, M ^{[1
]}

Steiner, M ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

来源：

SYNTHESIS-STUTTGART | 2006年 / 08期

关键词：

piperidines; stereoselective synthesis; beta-amino ester; Michael additions; fractional crystallization;

D O I：

10.1055/s-2006-926419

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(R)-Homopipecolic acid methyl ester has been prepared on a multigrant scale from 3,4-dihydro-2H-pyran in five steps and 36% overall yield. The stereochemistry was introduced via an asymmetric Michael addition and a fractional crystallization.

引用

页码：1386 / 1389

页数：4

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