Role of adhesion receptor trafficking in 3D cell migration

被引：35
|
作者：
Jacquemet, Guillaume [1 ]
Humphries, Martin J. [1 ]
Caswell, Patrick T. [1 ]
机构：
[1] Univ Manchester, Fac Life Sci, Wellcome Trust Ctr Cell Matrix Res, Manchester M13 9PT, Lancs, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 05期
基金：
英国惠康基金;
关键词：
CLATHRIN-MEDIATED ENDOCYTOSIS; PROMOTE INVASIVE MIGRATION; INTEGRIN ENDOCYTOSIS; ALPHA-5-BETA-1; INTEGRIN; RECYCLING PATHWAYS; SYNDECAN; ALPHA-V-BETA-3; RAB25; MICROENVIRONMENTS; DEGRADATION;
D O I：
10.1016/j.ceb.2013.05.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This review discusses recent advances in our understanding of adhesion receptor trafficking in vitro, and extrapolates them as far as what is currently possible towards an understanding of migration in three dimensions in vivo. Our specific focus is the mechanisms for endocytosis and recycling of the two major classes of cell-matrix adhesion receptors, integrins and syndecans. We review the signalling networks that are employed to regulate trafficking and conversely the effects of trafficking on signalling itself. We then define the contribution that this element of the migration process makes to processes such as wound healing and tumour invasion.
引用
收藏
页码：627 / 632
页数：6
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