Valproic acid adjunctive therapy for HIV-associated cognitive impairment: A first report

被引：67
|
作者：
Schifitto, G
Peterson, DR
Zhong, J
Ni, H
Cruttenden, K
Gaugh, M
Gendelman, HE
Boska, M
Gelbard, H
机构：
[1] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA
[2] Univ Rochester, Med Ctr, Dept Biostat, Rochester, NY 14642 USA
[3] Univ Rochester, Med Ctr, Dept Radiol, Rochester, NY 14642 USA
[4] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA
[5] Univ Nebraska, Med Ctr, Dept Radiol, Omaha, NE 68105 USA
来源：
NEUROLOGY | 2006年 / 66卷 / 06期
关键词：
D O I：
10.1212/01.wnl.0000204294.28189.03
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In vitro and animal model data demonstrate that valproic acid (VPA) can ameliorate HIV-associated neurotoxicity. The authors conducted a pilot 10-week placebo-controlled study of VPA 250 mg twice daily in 22 HIV-infected individuals with (n = 16) and without (n = 6) cognitive impairment. VPA was safe and well tolerated, with trends toward improved neuropsychological performance and brain metabolism in the impaired subjects.
引用
收藏
页码：919 / 921
页数：3
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