Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects

被引：169
|
作者：
Abdelkafi, Hajer [1 ]
Nay, Bastien [1 ]
机构：
[1] Museum Natl Hist Nat, Mol Commun & Adaptat Microorganismes UMR CNRS MNH, F-75005 Paris, France
来源：
NATURAL PRODUCT REPORTS | 2012年 / 29卷 / 08期
关键词：
FORMAL TOTAL-SYNTHESIS; SCHELHAMMERA PEDUNCULATA LILIACEAE; ASSISTED SEQUENTIAL INTRODUCTION; HIGHLY EFFICIENT SYNTHESIS; CHRONIC MYELOID-LEUKEMIA; BIOGENETIC-TYPE APPROACH; C-METHYLATED BIFLAVONE; STEREOSELECTIVE-SYNTHESIS; ENDOPHYTIC FUNGUS; ENANTIOSELECTIVE SYNTHESIS;
D O I：
10.1039/c2np20037f
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Cephalotaxus genus belongs to the Cephalotaxaceae family of conifers. Over the past decades it has proved to be a fruitful source of interesting natural products, especially alkaloids (cephalotaxine esters) and terpenoids (abietanes, troponoids), which often display medicinal properties, especially in the anticancer area. Homoharringtonine is active against some orphan leukaemia and is nowadays approaching marketability. A phytochemical update will be provided and the total synthesis of alkaloids and terpenoids will be discussed in detail.
引用
收藏
页码：845 / 869
页数：25
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