Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia

被引：29
|
作者：
Lanza, C
Volpe, G
Basso, G
Gottardi, E
Barisone, E
Spinelli, M
Ricotti, E
Cilli, V
Perfetto, F
Madon, E
Saglio, G
机构：
[1] UNIV TURIN,DIPARTIMENTO SCI PEDIAT & ADOLESCENZA,I-10124 TURIN,ITALY
[2] UNIV PADUA,DIPARTIMENTO SCI PEDIAT,I-35100 PADUA,ITALY
[3] UNIV TURIN,DIPARTIMENTO SCI BIOMED & ONCOL UMANA,I-10124 TURIN,ITALY
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 97卷 / 02期
关键词：
TEL; AML1; childhood ALL; translocations; prognosis;
D O I：
10.1046/j.1365-2141.1997.312676.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The t(12;21)(p13;q22) translocation has been described recently as the most recurrent genetic lesion in paediatric acute lymphoblastic leukaemias (ALLs). It has also been associated with B-precursor lineage involvement and good outcome. We tested 51 diagnostic paediatric ALLs and found 11 cases with molecular evidence of the t(12;21). Interestingly, amongst t(12;21) positive patients, we report three cases with hybrid phenotype, and two cases showing an aggressive and fatal disease. Our data show that the t(12;21) does not represent an independent good-risk indicator. Long follow-ups and additional molecular Investigations are needed to assess the prognostic and pathogenetic relevance of t(12;21) in childhood ALLs.
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页码：460 / 462
页数：3
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