Low prevalence of vitamin D deficiency in Ugandan HIV-infected patients with and without tuberculosis

被引:21
|
作者
Conesa-Botella, A. [1 ,2 ]
Goovaerts, O. [3 ,4 ]
Massinga-Loembe, M. [3 ]
Worodria, W. [5 ,6 ,7 ]
Mazakpwe, D. [6 ,7 ]
Luzinda, K. [6 ,7 ]
Mayanja-Kizza, H. [5 ,6 ]
Colebunders, R. [1 ,2 ]
Kestens, L. [3 ,4 ]
机构
[1] Inst Trop Med, Dept Clin Sci, B-2000 Antwerp, Belgium
[2] Univ Antwerp, B-2020 Antwerp, Belgium
[3] Inst Trop Med, Dept Biomed Sci, B-2000 Antwerp, Belgium
[4] Univ Antwerp, Dept Biomed Sci, B-2020 Antwerp, Belgium
[5] Makerere Univ, Coll Hlth Sci, Infect Dis Inst, Kampala, Uganda
[6] Makerere Univ, Mulago Hosp, Coll Hlth Sci, Dept Internal Med, Kampala, Uganda
[7] Infect Dis Network Treatment & Res Africa INTERAC, Kampala, Uganda
关键词
25-hydroxyvitamin D; HAART; immune reconstitution; RECONSTITUTION INFLAMMATORY SYNDROME; HUMAN-IMMUNODEFICIENCY-VIRUS; ANTIRETROVIRAL THERAPY; IMMIGRANTS; ADULTS;
D O I
10.5588/ijtld.11.0146
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
OBJECTIVE : To examine whether hypovitaminosis D is a risk factor for the development of tuberculosis (TB) associated immune reconstitution inflammatory syndrome (IRIS). METHODS: We measured serum 25-hydroxyvitamin D (25D) concentrations in four groups of patients at Mulago Hospital, Kampala, Uganda: 1) patients co-infected with TB and the human immunodeficiency virus (HIV) receiving anti-tuberculosis treatment (HIV+TB+; n = 92) who did and did not develop TB-IRIS after starting antiretroviral treatment (ART), 2) HIV-infected patients without TB (HIV+TB-; n = 20) starting ART, 3) non-HIV-infected individuals with TB (HIV+TB+; n = 27), and 4) those without TB (HIV-TB-; n = 23). RESULTS: The prevalence of optimal 25D levels (>75 nmol/l) was as follows: 59% in HIV+TB+, 65% in HIV+TB-, 63% in HIV-TB+ and 35% in HIV-TB- patients. 25D concentrations decreased during the first 3 months of ART in HIV+TB+ individuals who developed IRIS (P = 0.005) and those who did not (P = 0.002), and in HIV+TB- individuals (P = 0.015); however, 25D concentration in patients who did or did not develop TB-IRIS did not differ. CONCLUSION: The prevalence of optimal vitamin D status was relatively high in HIV-infected patients with and without TB living near the equator. No difference in 25D concentrations was observed between TB-IRIS and non-IRIS. However, 25D concentrations decreased during ART.
引用
收藏
页码:1517 / 1521
页数:5
相关论文
共 50 条
  • [31] Vitamin D Deficiency in HIV-Infected and HIV-Uninfected Women in the United States
    Adeyemi, Oluwatoyin M.
    Agniel, Denis
    French, Audrey L.
    Tien, Phyllis C.
    Weber, Kathleen
    Glesby, Marshall J.
    Villacres, Maria C.
    Sharma, Anjali
    Merenstein, Daniel
    Golub, Elizabeth T.
    Meyer, William
    Cohen, Mardge
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2011, 57 (03) : 197 - 204
  • [32] The Role of Vitamin D Deficiency in the Pathogenesis of Osteoporosis and in the Modulation of the Immune System in HIV-Infected Patients
    Allison C. Ross
    Grace A. McComsey
    Clinical Reviews in Bone and Mineral Metabolism, 2012, 10 (4): : 277 - 287
  • [33] Risk Factors for Vitamin D Deficiency in HIV-Infected Patients in the South Central United States
    Crutchley, Rustin D.
    Gathe, Joseph, Jr.
    Mayberry, Carl
    Trieu, Angel
    Abughosh, Susan
    Garey, Kevin W.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2012, 28 (05) : 454 - 459
  • [34] Prevalence of vitamin D deficiency in HIV/AIDS patients
    Aftab, Sabeen
    Butt, Nauman Ismat
    Ashfaq, Fahmina
    Malik, Tashia
    Arshad, Rabia
    Anser, Anida
    RAWAL MEDICAL JOURNAL, 2020, 45 (03): : 545 - 548
  • [35] PREVALENCE OF TUBERCULOSIS AND THE USE OF ISONIAZID PROPHYLAXIS IN ANERGIC HIV-INFECTED PATIENTS
    BARRIO, E
    CARBALLO, E
    CABARCOS, A
    AIDS, 1994, 8 (06) : 857 - 858
  • [36] Tuberculosis in HIV-infected patients in Honduras
    Andersson, K
    Aronsson, M
    Alvarado-Galvez, C
    Pineda-Garcia, L
    Hoffner, SE
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 1999, 3 (07) : 640 - 640
  • [37] Prevention of tuberculosis in HIV-infected patients
    Nahid, P
    Daley, CL
    CURRENT OPINION IN INFECTIOUS DISEASES, 2006, 19 (02) : 189 - 193
  • [38] ENDOBRONCHIAL TUBERCULOSIS IN HIV-INFECTED PATIENTS
    CALPE, JL
    CHINER, E
    LARRAMENDI, CH
    AIDS, 1995, 9 (10) : 1159 - 1164
  • [39] PLEURAL TUBERCULOSIS IN HIV-INFECTED PATIENTS
    GIL, V
    CORDERO, PJ
    GRESES, JV
    SOLER, JJ
    CHEST, 1995, 107 (06) : 1775 - 1776
  • [40] Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia
    Taylor, Steve M.
    Meshnick, Steven R.
    Worodria, William
    Andama, Alfred
    Davis, J. Lucian
    Cattamanchi, Adithya
    den Boon, Saskia
    Yoo, Samuel D.
    Goodman, Carol D.
    Huang, Laurence
    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2012, 72 (02) : 139 - 143