Diabetes and Chronic Heart Failure: From Diabetic Cardiomyopathy to Therapeutic Approach

被引：0
|
作者：
Dei Cas, A. [1 ]
Spigoni, V. [2 ]
Ridolfi, V. [1 ]
Metra, M. [2 ]
机构：
[1] Univ Parma, Unit Diabet & Prevent Associated Dis, Dept Clin & Expt Med, I-43100 Parma, Italy
[2] Univ Brescia, Dept Med & Surg Specialties Radiol Sci & Publ Hlt, Brescia, Italy
来源：
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS | 2013年 / 13卷 / 01期
关键词：
Chronic heart failure; diabetes mellitus; diabetic cardiomyopathy; molecular mechanisms; structural alteration; therapy; GLUCAGON-LIKE PEPTIDE-1; GLYCATION END-PRODUCTS; SARCOPLASMIC-RETICULUM CA2+-ATPASE; VENTRICULAR DIASTOLIC DYSFUNCTION; PRESERVED EJECTION FRACTION; TISSUE GROWTH-FACTOR; KINASE-C ISOFORMS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes and chronic heart failure are interrelated conditions with major medical and economic impact that have to be treated as a distinct entity. Several pathological mechanisms have been investigated and proposed to explain the structural and functional changes associated with diabetic cardiomyopathy. These mechanisms are likely to act synergically and may potentiate one the other. This review outlines recent advances in the pathophysiological mechanisms implicated in the development and progression of diabetic cardiomyopathy and in current therapeutic strategies.
引用
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页码：38 / 50
页数：13
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