Location of the influenza virus matrix protein M1 in the virion

被引：0
|
作者：
Ksenofontov, AL [1 ]
Fedorova, NV
Badun, GA
Timofeeva, TA
Grigor'ev, VB
Baratova, LA
Zhirnov, OP
机构：
[1] Moscow MV Lomonosov State Univ, Belozerskii Inst Physicochem Biol, Moscow 119899, Russia
[2] Russian Acad Sci, DI Ivanovskii Virol Inst, Moscow 119899, Russia
来源：
MOLECULAR BIOLOGY | 1999年 / 33卷 / 05期
关键词：
influenza virus; lipid membrane; M1 matrix protein; M1; location; tritium planigraphy; liposomes;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The M1 protein is commonly believed to form a protein matrix underlying the lipid membrane of the influenza virus. Upon bombardment of virus particles with thermally activated tritium atoms (tritium planigraphy), the surface glycoprotein hemagglutinin and the matrix protein Mi were labeled, but not the nucleocapsid protein. Virion integrity proved to be the same in virus specimens before and after bombardment. Data on the M1 shielding in the virion and the flux attenuation coefficient of the lipid, bilayer obtained with liposomes showed that the M1 matrix protein is embedded in the inner leaflet of the lipid membrane at the distance of 2.5-5 nm from the outer virion surface.
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页码：780 / 784
页数：5
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