Human renal cancer stem cells

被引：49
|
作者：
Bussolati, Benedetta [1 ,2 ]
Dekel, Benjamin [3 ,4 ]
Azzarone, Bruno [5 ]
Camussi, Giovanni [1 ,2 ]
机构：
[1] Univ Turin, Res Ctr Expt Med, Dept Internal Med, I-10124 Turin, Italy
[2] Univ Turin, Ctr Mol Biotechnol, I-10124 Turin, Italy
[3] Tel Aviv Univ, Sackler Sch Med, Pediat Stem Cell Res Inst, IL-69978 Tel Aviv, Israel
[4] Tel Aviv Univ, Sackler Sch Med, Div Pediat Nephrol, Edmond & Lily Safra Childrens Hosp,Sheba Med Ctr, IL-69978 Tel Aviv, Israel
[5] Hop Paul Brousse, INSERM UMR, Villejuif, France
来源：
CANCER LETTERS | 2013年 / 338卷 / 01期
关键词：
Renal cell carcinoma; Wilms' tumor; Tumor stem cells; Differentiation therapy; Angiogenesis; PROGENITOR CELLS; WILMS-TUMOR; IDENTIFICATION; CARCINOMA; DIFFERENTIATION; INTERLEUKIN-15; TUMORIGENESIS; MICROVESICLES; ANGIOGENESIS; POPULATION;
D O I：
10.1016/j.canlet.2012.05.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：141 / 146
页数：6
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