Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)

被引：62
|
作者：
Wang, Y
Zhang, YM
Yang, X
Han, WL
Liu, YN
Xu, QM
Zhao, R
Di, CH
Song, QS
Ma, DL [1 ]
机构：
[1] Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
来源：
LIFE SCIENCES | 2006年 / 78卷 / 06期
关键词：
chemokine; CLF; recombinant CKLF1; TARC/CCL17; CCR4; ligand;
D O I：
10.1016/j.lfs.2005.05.070
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：614 / 621
页数：8
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