Are patients with RA at increased risk of malignancy?

被引：1

作者：

Hyrich, Kimme L. ^{[1
,2
]}

机构：

[1] Univ Manchester, Arthrit Res Campaign Epidemiol Unit, Manchester M13 9PT, Lancs, England

[2] Manchester Royal Infirm, Manchester M13 9WL, Lancs, England

来源：

NATURE CLINICAL PRACTICE RHEUMATOLOGY | 2008年 / 4卷 / 12期

关键词：

anti-TNF; cancer; meta-analysis; rheumatoid arthritis;

D O I：

10.1038/ncprheum0924

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, Smitten and colleagues conducted a meta-analysis of the risk of cancer in patients with rheumatoid arthritis ( RA) compared with that in the general population. The authors found no important differences in the overall risk of cancer in patients with RA. However, the risk of lymphoma and lung cancer seemed to be increased, whereas colorectal cancer and breast cancer risk was decreased. With recent changes in the therapeutic approach to RA, concern has been raised about the role of anti-tumor necrosis factor therapies in inducing or increasing the risk of lymphoma and other malignancies. However, it is important to consider the baseline risk of these malignancies in patients with RA when placing the risk of new therapies into context.

引用

页码：632 / 633

页数：2

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