A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

被引：21
|
作者：
Hamieh, Saleh [1 ]
Ludlow, R. Frederick [2 ]
Perraud, Olivier [2 ]
West, Kevin R. [2 ]
Mattia, Elio [1 ]
Otto, Sijbren [1 ]
机构：
[1] Univ Groningen, Stratingh Inst, Ctr Syst Chem, NL-9747 AG Groningen, Netherlands
[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 21期
基金：
英国工程与自然科学研究理事会;
关键词：
CATION-PI INTERACTION; CHEMISTRY; BINDING; RECOGNITION;
D O I：
10.1021/ol302260n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and pi-pi a interactions.
引用
收藏
页码：5404 / 5407
页数：4
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