A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

被引：21

作者：

Hamieh, Saleh ^{[1
]}

Ludlow, R. Frederick ^{[2
]}

Perraud, Olivier ^{[2
]}

West, Kevin R. ^{[2
]}

Mattia, Elio ^{[1
]}

Otto, Sijbren ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst, Ctr Syst Chem, NL-9747 AG Groningen, Netherlands

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 21期

基金：

英国工程与自然科学研究理事会;

关键词：

CATION-PI INTERACTION; CHEMISTRY; BINDING; RECOGNITION;

D O I：

10.1021/ol302260n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and pi-pi a interactions.

引用

页码：5404 / 5407

页数：4

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