Beyond Prostate-specific Antigen - Future Biomarkers for the Early Detection and Management of Prostate Cancer

被引：13
|
作者：
Killick, E. [1 ,2 ]
Bancroft, E. [1 ,2 ]
Kote-Jarai, Z. [1 ]
Eeles, R. [1 ,2 ]
机构：
[1] Inst Canc Res, Sutton SM2 5PT, Surrey, England
[2] Royal Marsden NHS Fdn Trust, London, England
来源：
CLINICAL ONCOLOGY | 2012年 / 24卷 / 08期
关键词：
Biomarker; detection; prostate cancer; PSA; PERCENT FREE PSA; SINGLE-NUCLEOTIDE POLYMORPHISMS; GENOME-WIDE ASSOCIATION; MOLECULAR URINE ASSAY; QUALITY-OF-LIFE; BREAST-CANCER; RADICAL PROSTATECTOMY; FREE DNA; MAMMOGRAPHIC DENSITIES; TRANSITION ZONE;
D O I：
10.1016/j.clon.2012.05.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate-specific antigen is currently commonly used as a screening biomarker for prostate cancer, but it has limitations in both sensitivity and specificity. The development of novel biomarkers for early cancer detection has the potential to improve survival, reduce unnecessary investigations and benefit the health economy. Here we review the use and limitations of prostate-specific antigen and its subtypes, urinary biomarkers including PCA3, alpha-methylacyl-CoA racemase, the TMPRSS2-ERG fusion gene and microseminoprotein-beta, and other novel markers in both serum and urine. Many of these biomarkers are at early stages of development and require evaluation in prospective trials to determine their potential usefulness in clinical practice. Genetic profiling may allow for the targeting of high-risk populations for screening and may offer the opportunity to combine biomarker results with genotype to aid risk assessment. (C) 2012 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：545 / 555
页数：11
相关论文
共 50 条
  • [41] Is prostate-specific antigen velocity useful in early detection of prostate cancer? A critical appraisal of the evidence
    Etzioni, Ruth D.
    Ankerst, Donna P.
    Weiss, Noel S.
    Inoue, Lurdes Y. T.
    Thompson, Ian M.
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (20) : 1510 - 1515
  • [42] Serum Prostate-Specific Antigen for the Early Detection of Prostate Cancer: Always, Never, or Only Sometimes?
    Carroll, Peter R.
    Whitson, Jared M.
    Cooperberg, Matthew R.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (04) : 345 - 347
  • [43] Prostate-specific antigen vaccines for prostate cancer
    Hörig, H
    Lee, CSD
    Kaufman, HL
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2002, 2 (04) : 395 - 408
  • [44] Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
    Afshin Moradi
    Srilakshmi Srinivasan
    Judith Clements
    Jyotsna Batra
    [J]. Cancer and Metastasis Reviews, 2019, 38 : 333 - 346
  • [45] Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
    Moradi, Afshin
    Srinivasan, Srilakshmi
    Clements, Judith
    Batra, Jyotsna
    [J]. CANCER AND METASTASIS REVIEWS, 2019, 38 (03) : 333 - 346
  • [46] Prostate-specific antigen and screening for prostate cancer
    Han, M
    Gann, PH
    Catalona, WJ
    [J]. MEDICAL CLINICS OF NORTH AMERICA, 2004, 88 (02) : 245 - +
  • [47] Prostate-specific antigen density - A reliable parameter for the detection of prostate cancer?
    Thon, WF
    Gadban, F
    Truss, MC
    Kuczyk, M
    Hartmann, U
    Jonas, U
    [J]. WORLD JOURNAL OF UROLOGY, 1996, 14 (01) : 53 - 58
  • [48] Prostate-specific antigen for prostate cancer screening
    不详
    [J]. BJU INTERNATIONAL, 2023, 131 (03) : 266 - 266
  • [49] PROSTATE-SPECIFIC ANTIGEN AND PROSTATE-CANCER
    GUILLET, J
    ROLE, C
    DUC, AT
    PALU, M
    SENS, A
    FRANCOIS, H
    [J]. JOURNAL DE BIOPHYSIQUE ET DE BIOMECANIQUE, 1987, 11 (03): : 124 - 124
  • [50] Prostate-Specific Membrane Antigen: Gateway to Management of Advanced Prostate Cancer
    Unterrainer, Lena M.
    Calais, Jeremie
    Bander, Neil H.
    [J]. ANNUAL REVIEW OF MEDICINE, 2024, 75 : 49 - 66
12345