Beyond Prostate-specific Antigen - Future Biomarkers for the Early Detection and Management of Prostate Cancer

被引：13

作者：

Killick, E. ^{[1
,2
]}

Bancroft, E. ^{[1
,2
]}

Kote-Jarai, Z. ^{[1
]}

Eeles, R. ^{[1
,2
]}

机构：

[1] Inst Canc Res, Sutton SM2 5PT, Surrey, England

[2] Royal Marsden NHS Fdn Trust, London, England

来源：

CLINICAL ONCOLOGY | 2012年 / 24卷 / 08期

关键词：

Biomarker; detection; prostate cancer; PSA; PERCENT FREE PSA; SINGLE-NUCLEOTIDE POLYMORPHISMS; GENOME-WIDE ASSOCIATION; MOLECULAR URINE ASSAY; QUALITY-OF-LIFE; BREAST-CANCER; RADICAL PROSTATECTOMY; FREE DNA; MAMMOGRAPHIC DENSITIES; TRANSITION ZONE;

D O I：

10.1016/j.clon.2012.05.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate-specific antigen is currently commonly used as a screening biomarker for prostate cancer, but it has limitations in both sensitivity and specificity. The development of novel biomarkers for early cancer detection has the potential to improve survival, reduce unnecessary investigations and benefit the health economy. Here we review the use and limitations of prostate-specific antigen and its subtypes, urinary biomarkers including PCA3, alpha-methylacyl-CoA racemase, the TMPRSS2-ERG fusion gene and microseminoprotein-beta, and other novel markers in both serum and urine. Many of these biomarkers are at early stages of development and require evaluation in prospective trials to determine their potential usefulness in clinical practice. Genetic profiling may allow for the targeting of high-risk populations for screening and may offer the opportunity to combine biomarker results with genotype to aid risk assessment. (C) 2012 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

引用

页码：545 / 555

页数：11

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