Mobile rRNA methylase genes coding for erythromycin resistance in Actinobacillus actinomycetemcomitans

被引：15
|
作者：
Roe, DE
Weinberg, A
Roberts, MC
机构：
[1] UNIV WASHINGTON,DEPT PATHOBIOL,SEATTLE,WA 98195
[2] UNIV WASHINGTON,DEPT PERIODONT,SEATTLE,WA 98195
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1996年 / 37卷 / 03期
关键词：
D O I：
10.1093/jac/37.3.457
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We found that 17 (68%) of 25 Actinobacillus actinomycetemcomitans isolated from periodontally diseased sites had MICs of erythromycin greater than or equal to 8 mg/L. The isolates were hybridized with five rRNA methylase genes and gene mobility was determined. Twenty-four (96%) of 25 isolates hybridized with one or more rRNA methylase genes. Representative isolates were able to transfer erythromycin resistance to Haemophilus influenzae and Enterococcus faecalis recipients. The transconjugants were shown to carry rRNA methylase genes by DNA probe hybridization and had MICs of erythromycin 32 to 256 mg/L.
引用
收藏
页码：457 / 464
页数：8
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