Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora

被引：12

作者：

Zhu, Chuan-Zhi ^{[1
,2
]}

Hu, Bin-Yuan ^{[2
]}

Liu, Jia-Wang ^{[2
]}

Cai, Yi ^{[2
]}

Chen, Xin-Chun ^{[2
]}

Qin, Da-Peng ^{[2
]}

Cheng, Yong-Xian ^{[2
]}

Zhang, Zong-De ^{[1
]}

机构：

[1] Beijing TB & Thorac Tumor Res Inst, Mol Biol Lab, Beijing 101149, Peoples R China

[2] Shenzhen Univ Hlth Sci Ctr, Guangdong Key Lab Genome Stabil & Dis Prevent, Sch Pharmaceut Sci, Sch Basic Med, Shenzhen 518060, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 08期

关键词：

Resina Commiphora; plant resins; terpenoids; anti-Mycobacterium tuberculosis; SESQUITERPENOIDS; ACIDS;

D O I：

10.3390/molecules24081475

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known terpenoids (5-7) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds 1 and 2 both bear an O-bridge ring and feature a plausible [4 + 2] Diels-Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 M) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human cancer cells and THP-1 monocyte cells was examined.

引用

页数：11

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