Renal adaptation during hibernation

被引：32

作者：

Jani, Alkesh ^{[1
]}

Martin, Sandra L. ^{[2
]}

Jain, Swati ^{[1
]}

Keys, Daniel ^{[1
]}

Edelstein, Charles L. ^{[1
]}

机构：

[1] Univ Colorado, Sch Med, Div Renal Dis, Aurora, CO USA

[2] Univ Colorado, Sch Med, Dept Cell & Dev Biol, Aurora, CO USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2013年 / 305卷 / 11期

关键词：

kidney; torpor; metabolism; electrolytes; 13-LINED GROUND-SQUIRREL; HAMSTER MESOCRICETUS-AURATUS; ISCHEMIA-REPERFUSION INJURY; PROXIMAL CONVOLUTED TUBULE; GLOMERULAR-FILTRATION-RATE; NITRIC-OXIDE SYNTHASE; ANIMATION-LIKE STATE; NA-K-ATPASE; SUMMER HIBERNATION; ORGAN PRESERVATION;

D O I：

10.1152/ajprenal.00675.2012

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Hibernators periodically undergo profound physiological changes including dramatic reductions in metabolic, heart, and respiratory rates and core body temperature. This review discusses the effect of hypoperfusion and hypothermia observed during hibernation on glomerular filtration and renal plasma flow, as well as specific adaptations in renal architecture, vasculature, the renin-angiotensin system, and upregulation of possible protective mechanisms during the extreme conditions endured by hibernating mammals. Understanding the mechanisms of protection against organ injury during hibernation may provide insights into potential therapies for organ injury during cold storage and reimplantation during transplantation.

引用

页码：F1521 / F1532

页数：12

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