No association of paraoxonase gene polymorphism with atherosclerosis or Alzheimer's disease

被引：29
|
作者：
Sodeyama, N
Yamada, M
Itoh, Y
Suematsu, N
Matsushita, M
Otomo, E
Mizusawa, H
机构：
[1] Tokyo Med & Dent Univ, Dept Neurol, Bunkyo Ku, Tokyo 1138519, Japan
[2] Yokufukai Geriatr Hosp, Dept Internal Med, Tokyo, Japan
[3] Yokufukai Geriatr Hosp, Dept Pathol, Tokyo, Japan
[4] Tokyo Inst Psychiat, Dept Neuropathol, Tokyo, Japan
来源：
NEUROLOGY | 1999年 / 53卷 / 05期
关键词：
AD; paraoxonase; polymorphism; neuropathologic change;
D O I：
10.1212/WNL.53.5.1146
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Both AD and paraoxonase (PON) have been reported to be related to lipids and atherosclerosis, suggesting that the PON gene (PON) is a possible genetic risk factor for AD. We found no association of PON polymorphism with severity of atherosclerosis, densities of AD-type, neuropathologic change, or development of AD in 47 AD and 90 nondemented patients. Our study suggests that PON polymorphism does not play a. causal role in the development of atherosclerosis or AD.
引用
收藏
页码：1146 / 1148
页数：3
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