Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease

被引：20

作者：

Chapuis, Julien ^{[1
]}

Boscher, Maud ^{[1
]}

Bensemain, Faiza ^{[1
]}

Cottel, Dominique ^{[1
]}

Amouyel, Philippe ^{[1
]}

Lambert, Jean-Charles ^{[1
]}

机构：

[1] Univ Lille 2, INSERM, U744, Inst Pasteur, F-59019 Lille, France

来源：

NEUROBIOLOGY OF AGING | 2009年 / 30卷 / 01期

关键词：

Alzheimer; Paraoxonase; Association; Polymorphism; CORONARY-ARTERY-DISEASE; MOLECULAR-GENETICS; POLYMORPHISMS; GENOTYPE;

D O I：

10.1016/j.neurobiolaging.2007.05.021

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Recently, a region encompassing the promoter and intron 1 of the paraoxonase 1 pene (PON1) have been associated with the risk of developing Alzheimer's disease (AD) in a large pan-ethnic (Caucasian and African-American) dataset. We attempted to replicate this observation in a large French study of sporadic cases and controls. We confirmed that the proximal promoter and 5' sequence of the PON1 gene may harbor unknown functional variant(s) associated with the risk of developing AD. (C) 2007 Published by Elsevier Inc.

引用

页码：152 / 156

页数：5

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