Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum

被引：19
|
作者：
DeBarber, Andrea E. [1 ]
Geraci, Travis [1 ]
Colasurdo, Vincent P. [1 ]
Hackenmueller, Sarah A. [1 ]
Scanlan, Thomas S. [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97239 USA
来源：
JOURNAL OF CHROMATOGRAPHY A | 2008年 / 1210卷 / 01期
关键词：
3-Iodothyronamine; LC-MS/MS; Serum;
D O I：
10.1016/j.chroma.2008.09.022
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
There is great interest lately in the availability of analytical methods for quantification of 3-iodothyronamine from blood and tissues. To date, no validated method for determination of 3-iodothyronamine from biological matrices has been described. Detailed in this report is an LC-MS/MS method that permits accurate and reproducible quantification of pharmacological concentrations of 3-iodothyronamine from rat serum, with a 0.0008 M lower limit of quantification. Endogenous 3-iodothyronamine was observed from rodent and human serum (0.2 mL) at the method limit of detection. In summary, the LC-MS/MS method enables quantification of circulating 3-iodothyronamine to allow examination of a relationship with biological activity. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：55 / 59
页数：5
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