Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum

被引：19

作者：

DeBarber, Andrea E. ^{[1
]}

Geraci, Travis ^{[1
]}

Colasurdo, Vincent P. ^{[1
]}

Hackenmueller, Sarah A. ^{[1
]}

Scanlan, Thomas S. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97239 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 2008年 / 1210卷 / 01期

关键词：

3-Iodothyronamine; LC-MS/MS; Serum;

D O I：

10.1016/j.chroma.2008.09.022

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

There is great interest lately in the availability of analytical methods for quantification of 3-iodothyronamine from blood and tissues. To date, no validated method for determination of 3-iodothyronamine from biological matrices has been described. Detailed in this report is an LC-MS/MS method that permits accurate and reproducible quantification of pharmacological concentrations of 3-iodothyronamine from rat serum, with a 0.0008 M lower limit of quantification. Endogenous 3-iodothyronamine was observed from rodent and human serum (0.2 mL) at the method limit of detection. In summary, the LC-MS/MS method enables quantification of circulating 3-iodothyronamine to allow examination of a relationship with biological activity. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：55 / 59

页数：5

共 50 条

[1] Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry
Hackenmueller, Sarah A.
Scanlan, Thomas S.
[J]. JOURNAL OF CHROMATOGRAPHY A, 2012, 1256 : 89 - 97
[2] Quantification and Validation of Ertapenem Using a Liquid Chromatography-Tandem Mass Spectrometry Method
van Rijn, S. P.
Wessels, A. M. A.
Greijdanus, B.
Touw, D. J.
Alffenaar, J. W. C.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (06) : 3481 - 3484
[3] Determination of 3-iodothyronamine (3-T 1 AM) in mouse liver using liquid chromatography-tandem mass spectrometry
Li, Zhong-Min
Miller, Manuel
Gachkar, Sogol
Mittag, Jens
Schriever, Sonja C.
Pfluger, Paul T.
Schramm, Karl-Werner
De Angelis, Meri
[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 1165
[4] Quantification and validation of a liquid chromatography-tandem mass spectrometry assay for serum busulfan levels
Ekremoglu, M.
Kurdoglu, E. E.
Oktem, M.
[J]. FEBS JOURNAL, 2013, 280 : 279 - 279
[5] 3-Iodothyronamine cardiac metabolism: new insights resulting from liquid chromatography tandem mass spectrometry analysis
Chiellini, G.
Ghelardoni, S.
Saba, A.
Marchini, M.
Frascarelli, S.
Raffaelli, A.
Scanlan, T. S.
Zucchi, R.
[J]. CARDIOVASCULAR RESEARCH, 2010, 87 : S118 - S118
[6] Validation of a method for quantification of ketobemidone in human plasma with liquid chromatography-tandem mass spectrometry
Lampinen, M
Bondesson, U
Fredriksson, E
Hedeland, M
[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 789 (02): : 347 - 354
[7] Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Glycopyrrolate in Horse Plasma
Rumpler, M. J.
Sams, R. A.
Colahan, P.
[J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 2011, 35 (09) : 656 - 664
[8] Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantification of serum perfluorooctanoic acid and perfluorooctane sulfonate
Kim, S.
Nam, H.
Han, J.
Lee, E.
[J]. CLINICA CHIMICA ACTA, 2022, 530 : S120 - S120
[9] Liquid chromatography-tandem mass spectrometry for the quantification of total testosterone in serum
Shi, H.
Carlow, D.
[J]. CLINICAL CHEMISTRY, 2008, 54 (06) : A15 - A16
[10] Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantification of opiorphin in human saliva
Brkljacic, Lidija
Sabalic, Maja
Salaric, Ivan
Jeric, Ivanka
Alajbeg, Ivan
Nemet, Ina
[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 879 (32): : 3920 - 3926

← 1 2 3 4 5 →