Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum

被引：34
|
作者：
Tang, Jian [2 ]
Li, Hui-Liang [1 ]
Shen, Yun-Heng [1 ]
Jin, Hui-Zi [2 ]
Yan, Shi-Kai [2 ]
Liu, Run-Hui [1 ]
Zhang, Wei-Dong [1 ,2 ]
机构：
[1] Second Mil Med Univ, Dept Phytochem, Sch Pharm, Shanghai 200433, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
来源：
PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 08期
关键词：
Veratrum dahuricum; cyclopamine; germine; antitumor activity;
D O I：
10.1002/ptr.2463
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The antitumor activity of six extracts (ethanol extract, petroleum ether fraction, CHCl3 fraction, ethyl acetate fraction, n-butanol fraction and total alkaloids) from the rhizomes of Veratrum dahuricum, and six compounds (veratramine (1), jervine (2), germine (3), veramitaline (4), veratrosine (5) and cyclopamine (6)) from the ethanol extract were investigated in vitro. The 12 samples exhibited cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249. Among these samples, CHCl3 fraction, the total alkaloids, compounds 1 and 6 showed higher inhibitory activity, compound 3 selectively exhibited significant cytotoxicity to SW1990 and NCI-H249. Copyright (C) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码：1093 / 1096
页数：4
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