Phospholipid-based Immobilized Artificial Membrane (IAM) Chromatography: A Powerful Tool to Model Drug Distribution Processes

被引：10

作者：

Sobanska, Anna W. ^{[1
]}

Brzezinska, Elzbieta ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Analyt Chem, Ul Muszynskiego 1, PL-90151 Lodz, Poland

来源：

CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 44期

关键词：

IAM chromatography; blood-brain barrier; skin permeability; oral bioavailability; BLOOD-BRAIN-BARRIER; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN SERUM-ALBUMIN; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HUMAN INTESTINAL-ABSORPTION; STRUCTURALLY DIVERSE DRUGS; THIN-LAYER-CHROMATOGRAPHY; GRADIENT HPLC METHOD; PARTITION-COEFFICIENTS; POLAR INTERACTIONS;

D O I：

10.2174/1381612823666171018114331

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A review of applications of the Immobilized Artificial Membrane (IAM) chromatography in drug discovery is given. IAM chromatography is presented as a tool to predict the interactions of solutes with biomembranes, blood-brain barrier permeability, volume of distribution, oral and skin absorption of drugs and compared to other in vitro techniques used to study drug bioavailability (caco-2 cells, liposome partition). Unbound phosphatidylcholine based stationary phases are also discussed. Some new trends and ideas in the IAM chromatography are presented.

引用

页码：6784 / 6794

页数：11

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