Proteomic analysis of extracellular vesicles derived from Mycobacterium tuberculosis

被引：97
|
作者：
Lee, Jaewook [1 ]
Kim, Si-Hyun [1 ]
Choi, Dong-Sic [1 ]
Lee, Jong Seok [2 ]
Kim, Dae-Kyum [1 ]
Go, Gyeongyun [1 ]
Park, Seon-Min [3 ]
Kim, Si Hyun [4 ,5 ]
Shin, Jeong Hwan [4 ,5 ]
Chang, Chulhun L. [6 ,7 ]
Gho, Yong Song [1 ]
机构：
[1] Pohang Univ Sci & Technol, Dept Life Sci, Pohang 790784, South Korea
[2] Int TB Res Ctr, Microbiol Sect, Chang Won, South Korea
[3] Pohang Ctr Evaluat Biomat, Pohang, South Korea
[4] Inje Univ, Coll Med, Dept Lab Med, Busan, South Korea
[5] Inje Univ, Coll Med, Paik Inst Clin Res, Busan, South Korea
[6] Pusan Natl Univ, Sch Med, Dept Lab Med, Yangsan, South Korea
[7] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea
来源：
PROTEOMICS | 2015年 / 15卷 / 19期
关键词：
Diagnosis; Extracellular vesicles; Microbiology; Mycobacterium tuberculosis; MEMBRANE-VESICLES; QUANTITATIVE PROTEOMICS; PROTEIN; DATABASE; EXPORT;
D O I：
10.1002/pmic.201500037
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The release of extracellular vesicles, also known as outer membrane vesicles, membrane vesicles, exosomes, and microvesicles, is an evolutionarily conserved phenomenon from bacteria to eukaryotes. It has been reported that Mycobacterium tuberculosis releases extracellular vesicles harboring immunologically active molecules, and these extracellular vesicles have been suggested to be applicable in vaccine development and biomarker discovery. However, the comprehensive proteomic analysis has not been performed for M. tuberculosis extracellular vesicles. In this study, we identified a total of 287 vesicular proteins by four LC-MS/MS analyses with high confidence. In addition, we identified several vesicular proteins associated with the virulence of M. tuberculosis. This comprehensive proteome profile will help elucidate the pathogenic mechanism of M. tuberculosis. The data have been deposited to the ProteomeXchange with identifier PXD001160 ().
引用
收藏
页码：3331 / 3337
页数：7
相关论文
共 50 条
  • [41] Proteomic analysis of extracellular vesicles derived from platelet concentrates treated with Mirasol® identifies biomarkers of platelet storage lesion
    Hermida-Nogueira, Lidia
    Barrachina, Maria N.
    Izquierdo, Irene
    Garcia-Vence, Maria
    Lacerenza, Serena
    Bravo, Susana
    Castrillo, Azucena
    Garcia, Angel
    JOURNAL OF PROTEOMICS, 2020, 210
  • [42] Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa
    Choi, Dong-Sic
    Kim, Dae-Kyum
    Choi, Seng Jin
    Lee, Jaewook
    Choi, Jun-Pyo
    Rho, Sangchul
    Park, Sang-Hyun
    Kim, Yoon-Keun
    Hwang, Daehee
    Gho, Yong Song
    PROTEOMICS, 2011, 11 (16) : 3424 - 3429
  • [43] Proteomic analysis of purified protein derivative of Mycobacterium tuberculosis
    Prasad, Thottethodi Subrahmanya Keshava
    Verma, Renu
    Kumar, Satish
    Nirujogi, Raja Sekhar
    Sathe, Gajanan J.
    Madugundu, Anil K.
    Sharma, Jyoti
    Puttamallesh, Vinuth N.
    Ganjiwale, Anjali
    Myneedu, Vithal P.
    Chatterjee, Aditi
    Pandey, Akhilesh
    Harsha, H. C.
    Narayana, Jayasuryan
    CLINICAL PROTEOMICS, 2013, 10
  • [44] Proteomic analysis of purified protein derivative of Mycobacterium tuberculosis
    Thottethodi Subrahmanya Keshava Prasad
    Renu Verma
    Satish Kumar
    Raja Sekhar Nirujogi
    Gajanan J Sathe
    Anil K Madugundu
    Jyoti Sharma
    Vinuth N Puttamallesh
    Anjali Ganjiwale
    Vithal P Myneedu
    Aditi Chatterjee
    Akhilesh Pandey
    HC Harsha
    Jayasuryan Narayana
    Clinical Proteomics, 2013, 10
  • [45] Proteomic profiling of extracellular vesicles derived from human serum for the discovery of biomarkers in Avascular necrosis
    Sung, Soo-Eun
    Lim, Ju-Hyeon
    Kang, Kyung-Ku
    Choi, Joo-Hee
    Lee, Sijoon
    Sung, Minkyoung
    Park, Wook-Tae
    Kim, Young-In
    Seo, Min-Soo
    Lee, Gun Woo
    CLINICAL PROTEOMICS, 2024, 21 (01)
  • [46] The Immunomodulatory Signature of Extracellular Vesicles From Cardiosphere-Derived Cells: A Proteomic and miRNA Profiling
    Lopez, Esther
    Marinaro, Federica
    de los Angeles de Pedro, Maria
    Miguel Sanchez-Margallo, Francisco
    Gomez-Serrano, Maria
    Ponath, Viviane
    von Strandmann, Elke Pogge
    Jorge, Inmaculada
    Vazquez, Jesus
    Miguel Fernandez-Pereira, Luis
    Crisostomo, Veronica
    Alvarez, Veronica
    Casado, Javier G.
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [47] Isolation, Characterization and Proteomic Profiling of Small Extracellular Vesicles derived from Limbal Niche Cells
    Kistenmacher, Sebastian
    Martin, Gottfried
    Schwaemmle, Melanie Elisanna
    Nazarenko, Irina
    Bucher, Felicitas
    Tholen, Stefan
    Schilling, Oliver
    Giessl, Andreas
    Schloetzer-Schrehardt, Ursula
    Schlunck, Gunther R.
    Reinhard, Thomas
    Polisetti, Naresh
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (07)
  • [48] PROTEOMIC SIGNATURES OF EXTRACELLULAR VESICLES DERIVED FROM SYNOVIAL FLUID AND PLASMA OF PARTICIPANTS WITH KNEE OSTEOARTHRITIS
    Zhang, X.
    Ma, S.
    Reed, A.
    Ho, T.
    Waitt, G.
    Soderblom, E. J.
    Aliferis, C.
    Kraus, V. B.
    OSTEOARTHRITIS AND CARTILAGE, 2022, 30 : S121 - S121
  • [49] Establishment of minimum protein standards for Mycobacterium tuberculosis-derived extracellular vesicles through comparison of EV enrichment methods
    Joan M. Ryan
    Kimberly Shelton
    Monika Dzieciatkowska
    Nicole Kruh-Garcia
    Karen M. Dobos
    Mycobacteria, 1 (1):
  • [50] Regulatory roles of extracellular vesicles in immune responses against Mycobacterium tuberculosis infection
    Yan, Zhi
    Wang, Hua
    Mu, Lan
    Hu, Zhi-De
    Zheng, Wen-Qi
    WORLD JOURNAL OF CLINICAL CASES, 2021, 9 (25) : 7311 - 7318
12345