CRISPR-Cas: To Take Up DNA or Not-That Is the Question

被引：15
|
作者：
Weinberger, Ariel D. [1 ,2 ]
Gilmore, Michael S. [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA
来源：
CELL HOST & MICROBE | 2012年 / 12卷 / 02期
关键词：
TRANSFORMATION; INTERFERENCE;
D O I：
10.1016/j.chom.2012.07.007
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Landmark experiments in the 1920s showed that capsule switching is critical for Streptococcus pneumonia survival. Further studies demonstrated that capsule "transformation" occurs via DNA uptake. In this issue of Cell Host and Microbe, Bikard et al. (2012) show that CRISPR-Cas systems inhibit DNA uptake, selecting for the outgrowth of CRISPR-defective pneumococci.
引用
收藏
页码：125 / 126
页数：2
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