Conformation Control of Abiotic α-Helical Foldamers

被引：7

作者：

Perato, Serge ^{[1
]}

Fogha, Jade ^{[1
]}

Sebban, Muriel ^{[2
]}

Voisin-Chiret, Anne Sophie ^{[1
]}

Santos, Jana Sopkova-de Oliveira ^{[1
]}

Oulyadi, Hassan ^{[2
]}

Rault, Sylvain ^{[1
]}

机构：

[1] UNICAEN, CERMN, UPRES EA 4258, INC3M,FR CNRS 3038, F-14032 Caen, France

[2] Univ Rouen, COBRA UMR 6014, F-76821 Mont St Aignan, France

来源：

JOURNAL OF CHEMICAL INFORMATION AND MODELING | 2013年 / 53卷 / 10期

关键词：

PROTEIN-PROTEIN INTERACTIONS; MIMETICS; MIMICS; DESIGN;

D O I：

10.1021/ci400365y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

With the aim to find new protein protein inhibitors, a three part methodology was applied to oligophenylpyridines. Theoretical ring twist angle predictions have been validated by X-ray diffraction and molecular dynamics simulations with NMR constraints. Careful choice of substituent and nitrogen positions in oligophenylpyridyl foldamer units opens the way to conformational control of the side chain distribution of this alpha-helix mimic.

引用

页码：2671 / 2680

页数：10

共 50 条

[41] Introducing the Chiral Constrained α-Trifluoromethylalanine in Aib Foldamers to Control, Quantify and Assign the Helical Screw-Sense**
Bodero, Lizeth
Guitot, Karine
Lensen, Nathalie
Lequin, Olivier
Brigaud, Thierry
Ongeri, Sandrine
Chaume, Gregory
CHEMISTRY-A EUROPEAN JOURNAL, 2022, 28 (08)
[42] Single conformation spectroscopy and isomerization of synthetic foldamers and crown macrocycles
Zwier, Timothy S.
James, William H., III
Buchanan, Evan G.
Gellman, Samuel H.
Guo, Li
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
[43] Effects of Micelle Properties on the Conformation of Oligocholates and Importance of Rigidity of Foldamers
Zhang, Shiyong
Zhao, Yan
JOURNAL OF ORGANIC CHEMISTRY, 2012, 77 (01): : 556 - 562
[44] Fit to be tied: Conformation-directed macrocyclization of peptoid foldamers
Holub, Justin M.
Jang, Hangjun
Kirshenbaum, Kent
ORGANIC LETTERS, 2007, 9 (17) : 3275 - 3278
[45] Molecular dynamics studies of encapsulation and handedness inversion of helical foldamers
Abramyan, Ara M.
Liu, Zhiwei
Pophristic, Vojislava
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
[46] Helical arylamide foldamers: structure prediction by molecular dynamics simulations
Liu, Zhiwei
Abramyan, Ara M.
Pophristic, Vojislava
NEW JOURNAL OF CHEMISTRY, 2015, 39 (05) : 3229 - 3240
[47] Double-stranded helical foldamers as unique chiral materials
Yashima, Eiji
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
[48] Novel Helical Foldamers Based on the Conformational Properties of Aromatic Amides
Tanatani, Aya
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2019, 139 (04): : 581 - 589
[49] Mechanistic and dynamic insights into ligand encapsulation by helical arylamide foldamers
Abramyan, Ara M.
Liu, Zhiwei
Pophristic, Vojislava
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2014, 16 (38) : 20406 - 20410
[50] Helical Folding Competing with Unfolded Aggregation in Phenylene Ethynylene Foldamers
Luo, Zhouyang
Zhu, Ningbo
Zhao, Dahui
CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (31) : 11028 - 11034

← 1 2 3 4 5 →