Identification of the GABA(A) receptor alpha-subunit mRNA in rat intestine

被引：17

作者：

Zeiter, DK ^{[1
]}

Li, XS ^{[1
]}

Broussard, DL ^{[1
]}

机构：

[1] CHILDRENS HOSP,DIV GASTROENTEROL & NUTR,PHILADELPHIA,PA 19104

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 39卷 / 1-2期

关键词：

GABA(A) receptor; enteric nervous system; hybridization; in-situ; reverse transcription-polymerase chain reaction; gamma-aminobutyric acid; myenteric plexus; rat;

D O I：

10.1016/0169-328X(96)00077-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the expression of gamma-aminobutyric acid type A (GABA(A)) receptor alpha 1-, alpha 2- and alpha 3-subunit mRNAs in the rat intestine using reverse transcription and polymerase chain reaction. alpha 1- and alpha 3-, but not alpha 2-, subunit mRNAs were amplified from the proximal intestine, ileum, and colon. In-situ hybridization studies demonstrated the expression of alpha 1-subunit mRNA by myenteric neurons. GABA may be active via the GABA(A) receptor in the enteric nervous system.

引用

页码：241 / 244

页数：4

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