Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D2

被引：7

作者：

Kotoku, Naoyuki ^{[1
]}

Mizushima, Kohei ^{[1
]}

Tamura, Satoru ^{[1
]}

Kobayashi, Motomasa ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 10期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

cortistatin A; anti-angiogenesis; marine sponge; analogue synthesis; vitamin D-2; SPONGE CORTICIUM-SIMPLEX; STEROIDAL ALKALOIDS; BIOLOGICAL EVALUATION;

D O I：

10.1248/cpb.c13-00375

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D-2. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).

引用

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页码：1024 / 1029

页数：6

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