RETRACTED: Dexmedetomidine Inhibits Osteosarcoma Cell Proliferation and Migration, and Promotes Apoptosis by Regulating miR-520a-3p (Retracted Article)

被引：26
|
作者：
Wang, Xiaoyan [1 ]
Xu, Yongguang [1 ]
Chen, Xinlei [1 ]
Xiao, Jianmin [2 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Dept Anesthesiol, Jinan, Shandong, Peoples R China
[2] Ningjin Peoples Hosp, Dept Anesthesiol, 37 Kangping St, Ningjin 253400, Shandong, Peoples R China
来源：
ONCOLOGY RESEARCH | 2018年 / 26卷 / 03期
关键词：
Osteosarcoma (OS); Dexmedetomidine (DEX); miR-520a-3p; Cell proliferation and migration; AKT and ERK pathways; BREAST-CANCER; MICRORNA; CARCINOMA;
D O I：
10.3727/096504017X14982578608217
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study aimed to investigate the effect of dexmedetomidine (DEX) on osteosarcoma (OS) cell line MG63 and to explore the possible relationship between DEX and miR-520-3p in OS. The results showed that DEX could upregulate miR-520-3p, which directly targeted AKT1. Additionally, miR-520-3p also inhibited MG63 cell proliferation and migration, promoted apoptosis, and suppressed protein expressions of AKT, p-AKT, p-mTOR, and p-ER K1/2. DEX can inhibit OS cell proliferation and migration and promote apoptosis by upregulating the expression level of miR-520a-3p. DEX may serve as a potential therapeutic agent in OS treatment, and miR-520a-3p may be a potential target in the therapy of OS.
引用
收藏
页码：495 / 502
页数：8
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