Generation of induced pluripotent stem cell line, ZJUCHi002-A, from Charcot-Marie-Tooth disease type 2A (CMT2A) patient with a mutation of c.752C > T in MFN2

被引：2
|
作者：
Xu, Jiake [1 ,2 ,3 ]
Fu, Yong [5 ]
Xia, Weichun [1 ,2 ,3 ]
He, Jing [1 ,2 ,3 ]
Zou, Yan [6 ]
Ruan, Wencong [7 ]
Lou, Qi [8 ]
Li, Ying [1 ,2 ,3 ]
Pan, Jianwei [9 ]
Li, Haifeng [7 ]
Chen, Wei [1 ,2 ,3 ,4 ]
机构：
[1] Zhejiang Univ, Sch Med, Childrens Hosp, Hangzhou 310052, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Key Lab Diag & Treatment Neonatal Dis Zhejiang Pr, Hangzhou 310052, Zhejiang, Peoples R China
[3] Zhejiang Univ, Inst Translat Med, Sch Med, Hangzhou 310020, Zhejiang, Peoples R China
[4] Zhejiang Univ, Sch Med, Minist Hlth China, Dept Neurobiol,Key Lab Med Neurobiol, Hangzhou 310058, Zhejiang, Peoples R China
[5] Zhejiang Univ, Sch Med, Childrens Hosp, Otolaryngol Dept, Hangzhou, Zhejiang, Peoples R China
[6] Zhejiang Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China
[7] Zhejiang Univ, Sch Med, Childrens Hosp, Pediat Rehabil Dept, Hangzhou 310052, Zhejiang, Peoples R China
[8] Zhejiang Acad Med Sci, Expt Anim Ctr, Hangzhou 310013, Zhejiang, Peoples R China
[9] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Neurosurg, Hangzhou 310009, Zhejiang, Peoples R China
来源：
STEM CELL RESEARCH | 2019年 / 36卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.scr.2019.101411
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The human induced pluripotent stem cell (iPSC) line ZJUCHi002-A was established from renal epithelial cells present in urine (urinary cells) collected from an 8-year-old Charcot-Marie-Tooth disease type 2A (CMT2A) patient carrying point mutation in MFN2 (c.752C> T). Urinary cells were reprogrammed by retrovirus vectors containing reprogramming factors: OCT4, SOX2, KLF4 and c-MYC. The pluripotency, capacity of differentiation into 3 germ layers, silence of reprogramming factors and normal karyotype were all confirmed in this study.
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页数：5
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