DIABETIC REGULATION THROUGH BLOOD CONSTITUENTS' MODULATIONS ON TREATMENT WITH ALOE VERA IN ALLOXAN INDUCED DIABETIC RATS

To investigate the protective use of ethanolic extract of Aloe vera (AL) on blood glucose levels, hematology in diabetic rats. The Protective effect of AL in experimental was evaluated in this study. Three months old male wistar rats were divided into 4 groups (n=6) namely: control, control+ AL, (300mg/Kg body weight) diabetic (Alloxan 40mg/kg body weight), diabetic + AL (300mg/kg body weight). Hematological and biochemical parameters were estimated after 21 days of experimental period. Body weights and blood glucose levels diabetic rats were significantly decreased in AL treated diabetic rats when compared to control rats. But body weights were significantly decreased with an elevation in blood glucose levels were noticed in diabetic rats over control rats. The blood parameters such as WBC, serum albumin, total proteins, cholesterol, urea and creatinine levels were significantly elevated in diabetic rats than control rats. However, the same blood constituents were reverted to the level of control on treatment with AL in diabetic rats. In contrast, the hemoglobin, RBC and albumin contents were lowered with a statistical significance in diabetic rats over control. On treatment with AL the rate of decrease was minimized in hemoglobin and elevated in RBC on treatment with AL. But the rates of depletion noticed in serum albumin levels of diabetic rats were showed much depletion in AL treated rats than control. The results of this study showed that AL extract given orally for 21 days attenuated the extensive beneficial changes of hematological, biochemical parameters were recorded in alloxan diabetic rats.