Protective Effects of SGLT2 Inhibitor Luseogliflozin on Pancreatic Beta Cells in Obese Diabetic db/db Mice-"The Earlier and Longer, the Better"

被引:0
|
作者
Kimura, Tomohiko
Shimoda, Masashi
Nakanishi, Shuhei
Mune, Tomoatsu
Kaku, Kohei
Kaneto, Hideaki
机构
关键词
D O I
10.2337/db18-2111-P
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Erratum: Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice
    Linda A. Gallo
    Micheal S. Ward
    Amelia K. Fotheringham
    Aowen Zhuang
    Danielle J. Borg
    Nicole B. Flemming
    Ben M. Harvie
    Toni L. Kinneally
    Shang-Ming Yeh
    Domenica A. McCarthy
    Hermann Koepsell
    Volker Vallon
    Carol Pollock
    Usha Panchapakesan
    Josephine M. Forbes
    Scientific Reports, 6
  • [22] Protective effects of rutin on liver injury in type 2 diabetic db/db mice
    Liang, Weishi
    Zhang, Dandan
    Kang, Jiali
    Meng, Xubing
    Yang, Jingbo
    Yang, Lei
    Xue, Ning
    Gao, Qingyao
    Han, Shuying
    Gou, Xiangbo
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 107 : 721 - 728
  • [23] POTENTIAL ROLE FOR KETONE BODY METABOLISM IN AN SGLT2 INHIBITOR-MEDIATED ANTI-ALBUMINURIC EFFECT IN TYPE 2 DIABETIC DB/DB MICE
    Kume, Shinji
    Tomita, Issei
    Yamahara, Kosuke
    Yasuda-Yamahara, Mako
    Takeda, Naoko
    Osawa, Norihisa
    Chin-Kanasaki, Masami
    Kaneko, Tatsuroh
    Pieper, Michael
    Araki, Shin-Ichi
    Maegawa, Hiroshi
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2019, 34 : 504 - 504
  • [24] Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression
    Hirukawa, Hidenori
    Kaneto, Hideaki
    Shimoda, Masashi
    Kimura, Tomohiko
    Okauchi, Seizo
    Obata, Atsushi
    Kohara, Kenji
    Hamamoto, Sumiko
    Tawaramoto, Kazuhito
    Hashiramoto, Mitsuru
    Kaku, Kohei
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2015, 413 (0C) : 49 - 60
  • [25] A DPP-4 inhibitor remarkably suppresses foam cell formation in peritoneal macrophages obtained from db/db diabetic mice, comparison with a SGLT2 inhibitor and pioglitazone
    Terasaki, M.
    Nagashima, M.
    Hiromura, M.
    Notomi, K.
    Hirano, T.
    DIABETOLOGIA, 2014, 57 : S354 - S354
  • [26] SGLT2 Inhibitor Empagliflozin and DPP4 Inhibitor Linagliptin Reactivate Glomerular Autophagy in db/db Mice, a Model of Type 2 Diabetes
    Korbut, Anton I.
    Taskaeva, Iuliia S.
    Bgatova, Nataliya P.
    Muraleva, Natalia A.
    Orlov, Nikolai B.
    Dashkin, Maksim V.
    Khotskina, Anna S.
    Zavyalov, Evgenii L.
    Konenkov, Vladimir I.
    Klein, Thomas
    Klimontov, Vadim V.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (08)
  • [27] Effects of a New SGLT2 Inhibitor, Luseogliflozin, on Diabetic Nephropathy in T2DN Rats
    Kojima, Naoki
    Williams, Jan M.
    Takahashi, Teisuke
    Miyata, Noriyuki
    Roman, Richard J.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2013, 345 (03): : 464 - 472
  • [28] Treatment of Hyperglycemia with the SGLT2 Inhibitor Empagliflozin Ameliorates Markers of Islet Endothelial Dysfunction in C57BL/KsJ.db/db Diabetic Mice
    Hull, Rebecca L.
    Hogan, Meghan F.
    DIABETES, 2017, 66 : A568 - A568
  • [29] Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice (vol 6, 26428, 2016)
    Gallo, Linda A.
    Ward, Micheal S.
    Fotheringham, Amelia K.
    Zhuang, Aowen
    Borg, Danielle J.
    Flemming, Nicole B.
    Harvie, Ben M.
    Kinneally, Toni L.
    Yeh, Shang-Ming
    McCarthy, Domenica A.
    Koepsell, Hermann
    Vallon, Volker
    Pollock, Carol
    Panchapakesan, Usha
    Forbes, Josephine M.
    SCIENTIFIC REPORTS, 2016, 6
  • [30] Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice
    Fushimi, Yoshiro
    Obata, Atsushi
    Sanada, Junpei
    Nogami, Yuka
    Ikeda, Tomoko
    Yamasaki, Yuki
    Obata, Yoshiyuki
    Shimoda, Masashi
    Nakanishi, Shuhei
    Mune, Tomoatsu
    Kaku, Kohei
    Kaneto, Hideaki
    SCIENTIFIC REPORTS, 2021, 11 (01)