Adenosine-5′-carboxylic acid peptidyl derivatives as inhibitors of protein kinases

被引：27

作者：

Loog, M

Uri, A

Raidaru, G

Järv, J

Ek, P

机构：

[1] Tartu State Univ, Inst Chem Phys, EE-51014 Tartu, Estonia

[2] Uppsala Univ, Dept Med Biochem & Microbiol, S-75123 Uppsala, Sweden

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(99)00210-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new class of protein kinase bisubstrate-analog inhibitors was designed on the basis of adenosine-5'-carboxylic acid derivatives, where a short peptide was attached to the 5'-carbon atom of the adenosine sugar moiety via a linker chain. The potency and selectivity of these inhibitors were adjusted by relevant combination of these structural fragments, resembling the structure of the bisubstrate complex of the peptide phosphorylation reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1447 / 1452

页数：6

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