Glucocorticoid sensitivity of T-cell lymphoblastic leukemia/lymphoma is associated with glucocorticoid receptor-mediated inhibition of Notch1 expression

被引：31
|
作者：
Cialfi, S. [1 ,2 ]
Palermo, R. [1 ]
Manca, S. [1 ]
Checquolo, S. [1 ]
Bellavia, D. [1 ]
Pelullo, M. [1 ]
Quaranta, R. [1 ]
Donninic, C. [2 ]
Gulino, A. [1 ]
Screpanti, I. [1 ]
Talora, C. [1 ]
机构：
[1] Univ Roma La Sapienza, Dept Mol Med, Rome, Italy
[2] Univ Roma La Sapienza, Dept Pediat & Infantile Neuropsychiat, Rome, Italy
来源：
LEUKEMIA | 2013年 / 27卷 / 02期
关键词：
SIGNALING PATHWAY; LEUKEMIA; RESISTANCE; THERAPY; COMPLEX; CANCER;
D O I：
10.1038/leu.2012.192
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：485 / 488
页数：4
相关论文
共 50 条
  • [41] Transcriptional regulatory networks downstream of NOTCH1 in T-cell acute lymphoblastic leukemia.
    Palomero, T
    Odom, DT
    Margolin, A
    Aster, J
    Califano, A
    Young, RA
    Look, AT
    Ferrando, AA
    BLOOD, 2005, 106 (11) : 219A - 219A
  • [42] Mutations of the Notch1 gene in T-cell acute lymphoblastic leukemia: analysis in adults and children
    S-Y Lee
    K Kumano
    S Masuda
    A Hangaishi
    J Takita
    K Nakazaki
    M Kurokawa
    Y Hayashi
    S Ogawa
    S Chiba
    Leukemia, 2005, 19 : 1841 - 1843
  • [43] Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
    Teresa Palomero
    Maria Luisa Sulis
    Maria Cortina
    Pedro J Real
    Kelly Barnes
    Maria Ciofani
    Esther Caparros
    Jean Buteau
    Kristy Brown
    Sherrie L Perkins
    Govind Bhagat
    Archana M Agarwal
    Giuseppe Basso
    Mireia Castillo
    Satoru Nagase
    Carlos Cordon-Cardo
    Ramon Parsons
    Juan Carlos Zúñiga-Pflücker
    Maria Dominguez
    Adolfo A Ferrando
    Nature Medicine, 2007, 13 : 1203 - 1210
  • [44] Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
    Palomero, Teresa
    Sulis, Maria Luisa
    Cortina, Maria
    Real, Pedro J.
    Barnes, Kelly
    Ciofani, Maria
    Caparros, Esther
    Buteau, Jean
    Brown, Kristy
    Perkins, Sherrie L.
    Bhagat, Govind
    Agarwal, Archana M.
    Basso, Giuseppe
    Castillo, Mireia
    Nagase, Satoru
    Cordon-Cardo, Carlos
    Parsons, Ramon
    Zuniga-Pflucker, Juan Carlos
    Dominguez, Maria
    Ferrando, Adolfo A.
    NATURE MEDICINE, 2007, 13 (10) : 1203 - 1210
  • [45] Activating NOTCH1 mutations are associated with good treatment response in childhood T-cell acute lymphoblastic leukemia.
    Breit, S
    Stanulla, M
    Flohr, T
    Schrappe, M
    Ludwig, WD
    Tolle, G
    Happich, M
    Muckenthaler, MM
    Kulozik, AE
    BLOOD, 2005, 106 (11) : 417A - 417A
  • [46] NOTCH1 Transcriptionally Activates Deptor and Promotes AKT Activation in Acute T-Cell Lymphoblastic Leukemia
    Liu, Hudan
    Hu, Yufeng
    Su, Hexiu
    Ye, Qi
    Wang, Zhaojing
    Huang, Liang
    Wang, Qian
    Chen, Suning
    Zhou, Jianfeng
    Liu, Shuangyou
    Qing, Guoliang
    BLOOD, 2014, 124 (21)
  • [47] NOTCH1 mutations in T-cell acute lymphoblastic leukemia:: Prognostic significance and implication in multifactorial leukemogenesis
    Zhu, Yong-Mei
    Zhao, Wei-Li
    Fu, Jian-Fei
    Shi, Jing-Yi
    Pan, Qin
    Hu, Jiong
    Gao, Xiao-Dong
    Chen, Bing
    Li, Jun-Min
    Xiong, Shu-Min
    Gu, Long-Jun
    Tang, Jing-Yi
    Liang, Hui
    Jiang, Hui
    Xue, Yong-Quan
    Shen, Zhi-Xiang
    Chen, Zhu
    Chen, Sai-Juan
    CLINICAL CANCER RESEARCH, 2006, 12 (10) : 3043 - 3049
  • [48] High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia
    Chiang, Mark Y.
    Wang, Qing
    Gormley, Anna C.
    Stein, Sarah J.
    Xu, Lanwei
    Shestova, Olga
    Aster, Jon C.
    Pear, Warren S.
    BLOOD, 2016, 128 (18) : 2229 - 2240
  • [49] Oncogenic Kras and Notch-1 cooperate in T-cell acute lymphoblastic leukemia/lymphoma
    Mansour, Marc R.
    EXPERT REVIEW OF HEMATOLOGY, 2009, 2 (02) : 133 - 136
  • [50] NOTCH1 pathway activating mutations and clonal evolution in pediatric T-cell acute lymphoblastic leukemia
    Kimura, Shunsuke
    Seki, Masafumi
    Yoshida, Kenichi
    Shiraishi, Yuichi
    Akiyama, Masaharu
    Koh, Katsuyoshi
    Imamura, Toshihiko
    Manabe, Atsushi
    Hayashi, Yasuhide
    Kobayashi, Masao
    Oka, Akira
    Miyano, Satoru
    Ogawa, Seishi
    Takita, Junko
    CANCER SCIENCE, 2019, 110 (02) : 784 - 794
12345