Acaricidal activity of usnic acid and sodium usnic acid against Psoroptes cuniculi in vitro

被引：10

作者：

Shang, Xiaofei ^{[1
]}

Miao, Xiaolou ^{[1
]}

Lv, Huiping ^{[2
]}

Wang, Dongsheng ^{[1
]}

Zhang, Jiqin ^{[1
]}

He, Hua ^{[3
]}

Yang, Zhiqiang ^{[1
]}

Pan, Hu ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Key Lab New Anim Drug Project, Gansu Prov Key Lab Vet Pharmaceut Dev, Minist Agr,Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Peoples R China

[2] Peoples Hosp Jingchuan Cty, Dept Emergency, Jingchuan 744300, Peoples R China

[3] Wenzhou Med Coll, Dept Pharm, Wenzhou 325035, Peoples R China

来源：

PARASITOLOGY RESEARCH | 2014年 / 113卷 / 06期

关键词：

Acaricidal activity; Usnic acid; Sodium usnic acid; Psoroptes cuniculi; SCABIEI VAR. CUNICULI; ESSENTIAL OIL; EFFICACY; EXTRACTS;

D O I：

10.1007/s00436-014-3910-0

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Usnic acid, a major active compound in lichens, was first isolated in 1884. Since then, usnic acid and its sodium salt (sodium usnic acid) have been used in medicine, perfumery, cosmetics, and other industries due to its extensive biological activities. However, its acaricidal activity has not been studied. In this paper, we investigated the acaricidal activity of usnic acid and sodium usnic acid against Psoroptes cuniculi in vitro. After evaluating the acaricidal activity and toxicity of usnic acid and sodium usnic acid in vitro, the results showed that at doses of 250, 125, and 62.5 mg/ml, usnic acid and sodium usnic acid can kill mites with 91.67, 85.00, and 55.00 % and 100, 100, and 60.00 % mortality after treatment 24 h. The LT50 values were 4.208, 8.249, and 16.950 h and 3.712, 7.339, and 15.773 h for usnic acid and sodium usnic acid, respectively. Sodium usnic acid has a higher acaricidal activity than usnic acid, which may be related to the difference in their structures.

引用

页码：2387 / 2390

页数：4

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