Do Current Animal Models of Intracerebral Hemorrhage Mirror the Human Pathology?

被引：14

作者：

Adeoye, Opeolu ^{[1
,4
,5
]}

Clark, Joseph F. ^{[3
]}

Khatri, Pooja ^{[3
]}

Wagner, Kenneth R. ^{[2
,3
]}

Zuccarello, Mario ^{[4
]}

Pyne-Geithman, Gail J. ^{[4
]}

机构：

[1] Univ Cincinnati Med Ctr, UC Neurosci Inst, Dept Emergency Med, Div Neurocrit Care, Cincinnati, OH 45267 USA

[2] Vet Adm Med Ctr, Cincinnati, OH 45220 USA

[3] Univ Cincinnati, Dept Neurol, Cincinnati, OH USA

[4] Univ Cincinnati, Dept Neurosurg, Cincinnati, OH USA

[5] Univ Cincinnati, Dept Emergency Med, Cincinnati, OH USA

来源：

TRANSLATIONAL STROKE RESEARCH | 2011年 / 2卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Intracerebral hemorrhage; Animal models; Stroke; Translation; TISSUE-PLASMINOGEN-ACTIVATOR; CEREBRAL AMYLOID ANGIOPATHY; RAT MODEL; EDEMA DEVELOPMENT; BLOOD-FLOW; STROKE; HYDROCEPHALUS; UPDATE; PERMEABILITY; COLLAGENASE;

D O I：

10.1007/s12975-010-0037-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although intracerebral hemorrhage (ICH) has no proven treatment, well-designed studies using animal models of ICH may lead to the development of novel therapies. We briefly review current animal models of ICH. Furthermore, we discuss how these models may be utilized and targeted to facilitate translation of preclinical findings to the clinical arena.

引用

页码：17 / 25

页数：9

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