Efavirenz concentrations in HIV-infected patients with and without viral hepatitis

被引：15
|
作者：
Pereira, Sofia A. [1 ]
Caixas, Umbelina [1 ,3 ]
Branco, Teresa [3 ]
Germano, Isabel [3 ]
Lampreia, Fatima [3 ]
Papoila, Ana L. [2 ]
Monteiro, Emilia C. [1 ]
机构：
[1] Univ Nova Lisboa, Fac Med Sci, Dept Pharmacol, P-1169056 Lisbon, Portugal
[2] Univ Nova Lisboa, Fac Med Sci, Dept Biostat, P-1169056 Lisbon, Portugal
[3] Ctr Hosp Lisboa Zona Cent, Lisbon, Portugal
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2008年 / 66卷 / 04期
关键词：
efavirenz concentrations; liver function; viral hepatitis co-infection;
D O I：
10.1111/j.1365-2125.2008.03238.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
AIMS Data on efavirenz in HIV/viral hepatitis co-infected patients is non-consensual, probably due to liver function heterogeneity in the patients included. METHODS A case control study was performed on 27 HIV-infected patients, with controlled and homogenous markers of hepatic function, either mono-infected or co-infected with HBV/HCV, to ascertain the influence of viral hepatitis on efavirenz concentrations over a 2-year follow-up period. RESULTS No differences were found in efavirenz concentrations between groups both during and at the end of the follow-up period: control (2.43 +/- 1.91 mg l(-1)) vs. co-infected individuals (2.37 +/- 0.37 mg l(-1)). CONCLUSION It was concluded that HBV/HCV infections in themselves do not predispose to an overexposure to efavirenz.
引用
收藏
页码：551 / 555
页数：5
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