Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies

Background: It remains unclear whether coffee intake is associated with the risk of hypertension. This study aimed to investigate the association between coffee intake and the risk of hypertension by using a meta-analysis of cohort studies.Methods: PubMed and Embase were searched using keywords in September 2022 to identify studies on coffee intake and the risk of hypertension.Results: We included a total of 12 longitudinal cohort studies, which involved a total of 64,650 incident cases of hypertension among 314,827 participants. In a random effects model meta-analysis of all the studies, coffee intake was not significantly associated with the risk of hypertension (relative risk [RR], 0.94; 95% confidence interval [CI], 0.89-1.00; I2 = 40.8%; n = 12). In the subgroup meta-analysis, coffee intake was associated with a decreased risk of hypertension in studies conducted in America (RR, 0.93; 95% CI, 0.87-0.98; I2 = 4.6%; n = 5) and in low-quality studies (RR, 0.92; 95% CI, 0.88-0.96; I2 = 0.0%; n = 7). In the remaining subgroup meta-analyses by amount of coffee intake, gender, type of coffee (decaffeinated vs. caffeinated), smoking, and years of follow-up, coffee intake was not significantly associated with the risk of hypertension.Conclusion: The current meta-analysis showed that coffee intake is not associated with the risk of hypertension.