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Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Key Lab Biomed Effects Nanomat & Nanosafety,Key L, Beijing 100190, Peoples R China Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Key Lab Biomed Effects Nanomat & Nanosafety,Key L, Beijing 100190, Peoples R China