SB1518, a novel JAK2/FLT3 inhibitor for the treatment of myeloid malignancies

被引:0
|
作者
Hart, Stefan [1 ]
Goh, Kee Chuan [1 ]
Novotny-Diermayr, Veronica Veronica [1 ]
Tan, Yong Cheng [1 ]
Madan, Babita [1 ]
Amalini, Chithra [1 ]
Loh, Yung Kiang [1 ]
Ong, Lai Chun [1 ]
Williams, Anthony [1 ]
Lee, Angeline [1 ]
Poulsen, Anders [1 ]
Jayaraman, Ramesh [1 ]
Ethirajulu, Kantharaj [1 ]
Dymock, Brian W. [1 ]
Wood, Jeanette M. [1 ]
机构
[1] S BIO PTE LTD, Singapore, Singapore
关键词
D O I
10.1158/1538-7445.AM2011-3570
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3570
引用
收藏
页数:1
相关论文
共 50 条
  • [41] PACRITINIB Inhibitor of Tyrosine-Protein Kinase JAK2 Inhibitor of FLT-3 Treatment of Myelofibrosis
    Verstovsek, S.
    Machida, C.
    Dean, J. P.
    Myint, H.
    DRUGS OF THE FUTURE, 2013, 38 (06) : 375 - 386
  • [42] Studies on the anti-psoriasis effects and its mechanism of a dual JAK2/FLT3 inhibitor flonoltinib maleate
    Zhu, Jiali
    Yang, Tao
    Tang, Minghai
    Yang, Zhuang
    Pei, Heying
    Ye, Haoyu
    Tang, Yu
    Cheng, Zhixuan
    Lin, Ping
    Chen, Lijuan
    BIOMEDICINE & PHARMACOTHERAPY, 2021, 137
  • [43] Phase I Study of a Novel Oral JAK-2 Inhibitor SB1518 In Patients with Relapsed Lymphoma: Evidence of Clinical and Biologic Activity In Multiple Lymphoma Subtypes
    Younes, Anas
    Fanale, Michelle A.
    McLaughlin, Peter
    Copeland, Amanda
    Zhu, Joy
    Faria, Silvania de Castro
    BLOOD, 2010, 116 (21) : 1167 - 1167
  • [44] A novel and potent FLT3 and IRAK4 dual inhibitor for the treatment of acute myeloid leukemia
    Yang, Rui
    Wu, Lei
    Zhang, Bing
    Xiang, Michael
    Wang, Suyue
    Xiang, Camille
    Lu, Zhijian
    Xiang, Jason
    CANCER RESEARCH, 2023, 83 (07)
  • [45] Orally efficacious, selective FLT3 inhibitor for the treatment of acute myeloid leukemia
    Kreutter, Kevin
    Baindur, Nand
    Xu, Guozhang
    Kim, Alexander J.
    Baumann, Christian A.
    Tuman, Robert W.
    Johnson, Dana L.
    Gaul, Micheal D.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [46] Rational polypharmacological targeting of FLT3, JAK2, ABL, and ERK1 suppresses the adaptive resistance to FLT3 inhibitors in AML
    Azhar, Mohammad
    Kincaid, Zachary
    Kesarwani, Meenu
    Menke, Jacob
    Schwieterman, Joshua
    Ansari, Sekhu
    Reaves, Angela
    Ahmed, Arhama
    Shehzad, Rammsha
    Khan, Areeba
    Syed, Nuha
    Amir, Noor
    Wunderlich, Mark
    Latif, Tahir
    Seibel, William
    Azam, Mohammad
    BLOOD ADVANCES, 2023, 7 (08) : 1460 - 1476
  • [47] Preclinical activity and a pilot phase I study of pacritinib, an oral JAK2/FLT3 inhibitor, and chemotherapy in FLT3-ITD-positive AML
    Jae Yoon Jeon
    Qiuhong Zhao
    Daelynn R. Buelow
    Mitch Phelps
    Alison R. Walker
    Alice S. Mims
    Sumithira Vasu
    Gregory Behbehani
    James Blachly
    William Blum
    Rebecca B. Klisovic
    John C. Byrd
    Ramiro Garzon
    Sharyn D. Baker
    Bhavana Bhatnagar
    Investigational New Drugs, 2020, 38 : 340 - 349
  • [48] Preclinical activity and a pilot phase I study of pacritinib, an oral JAK2/FLT3 inhibitor, and chemotherapy in FLT3-ITD-positive AML
    Jeon, Jae Yoon
    Zhao, Qiuhong
    Buelow, Daelynn R.
    Phelps, Mitch
    Walker, Alison R.
    Mims, Alice S.
    Vasu, Sumithira
    Behbehani, Gregory
    Blachly, James
    Blum, William
    Klisovic, Rebecca B.
    Byrd, John C.
    Garzon, Ramiro
    Baker, Sharyn D.
    Bhatnagar, Bhavana
    INVESTIGATIONAL NEW DRUGS, 2020, 38 (02) : 340 - 349
  • [49] TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties
    Goh, K. C.
    Novotny-Diermayr, V.
    Hart, S.
    Ong, L. C.
    Loh, Y. K.
    Cheong, A.
    Tan, Y. C.
    Hu, C.
    Jayaraman, R.
    William, A. D.
    Sun, E. T.
    Dymock, B. W.
    Ong, K. H.
    Ethirajulu, K.
    Burrows, F.
    Wood, J. M.
    LEUKEMIA, 2012, 26 (02) : 236 - 243
  • [50] TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties
    K C Goh
    V Novotny-Diermayr
    S Hart
    L C Ong
    Y K Loh
    A Cheong
    Y C Tan
    C Hu
    R Jayaraman
    A D William
    E T Sun
    B W Dymock
    K H Ong
    K Ethirajulu
    F Burrows
    J M Wood
    Leukemia, 2012, 26 : 236 - 243