SB1518, a novel JAK2/FLT3 inhibitor for the treatment of myeloid malignancies

被引:0
|
作者
Hart, Stefan [1 ]
Goh, Kee Chuan [1 ]
Novotny-Diermayr, Veronica Veronica [1 ]
Tan, Yong Cheng [1 ]
Madan, Babita [1 ]
Amalini, Chithra [1 ]
Loh, Yung Kiang [1 ]
Ong, Lai Chun [1 ]
Williams, Anthony [1 ]
Lee, Angeline [1 ]
Poulsen, Anders [1 ]
Jayaraman, Ramesh [1 ]
Ethirajulu, Kantharaj [1 ]
Dymock, Brian W. [1 ]
Wood, Jeanette M. [1 ]
机构
[1] S BIO PTE LTD, Singapore, Singapore
关键词
D O I
10.1158/1538-7445.AM2011-3570
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3570
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia
    Hart, S.
    Goh, K. C.
    Novotny-Diermayr, V.
    Tan, Y. C.
    Madan, B.
    Amalini, C.
    Ong, L. C.
    Kheng, B.
    Cheong, A.
    Zhou, J.
    Chng, W. J.
    Wood, J. M.
    BLOOD CANCER JOURNAL, 2011, 1 : e44 - e44
  • [2] Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia
    S Hart
    K C Goh
    V Novotny-Diermayr
    Y C Tan
    B Madan
    C Amalini
    L C Ong
    B Kheng
    A Cheong
    J Zhou
    W J Chng
    J M Wood
    Blood Cancer Journal, 2011, 1 : e44 - e44
  • [3] Phase 1/2 Study of SB1518, a Novel JAK2/FLT3 Inhibitor, In the Treatment of Primary Myelofibrosis
    Verstovsek, Srdan
    Deeg, H. Joachim
    Odenike, Olatoyosi
    Zhu, Joy
    Kantarjian, Hagop
    Estrov, Zeev
    Scott, Bart Lee
    Thomas, Deborah A.
    BLOOD, 2010, 116 (21) : 1271 - 1271
  • [4] SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
    Hart, S.
    Goh, K. C.
    Novotny-Diermayr, V.
    Hu, C. Y.
    Hentze, H.
    Tan, Y. C.
    Madan, B.
    Amalini, C.
    Loh, Y. K.
    Ong, L. C.
    William, A. D.
    Lee, A.
    Poulsen, A.
    Jayaraman, R.
    Ong, K. H.
    Ethirajulu, K.
    Dymock, B. W.
    Wood, J. W.
    LEUKEMIA, 2011, 25 (11) : 1751 - 1759
  • [5] SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
    S Hart
    K C Goh
    V Novotny-Diermayr
    C Y Hu
    H Hentze
    Y C Tan
    B Madan
    C Amalini
    Y K Loh
    L C Ong
    A D William
    A Lee
    A Poulsen
    R Jayaraman
    K H Ong
    K Ethirajulu
    B W Dymock
    J W Wood
    Leukemia, 2011, 25 : 1751 - 1759
  • [6] CHARACTERIZATION OF THE PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES OF PACRITINIB (SB1518), A NOVEL ORAL JAK2/FLT3 INHIBITOR, IN PATIENTS WITH MYELOFIBROSIS, AML AND LYMPHOMA
    Al-Fayoumi, S.
    Wang, L.
    Dean, J.
    Benner, S.
    HAEMATOLOGICA, 2013, 98 : 406 - 406
  • [7] Design, synthesis and SAR studies leading to SB1518, a novel macrocyclic JAK2/FLT3 inhibitor in phase 2 clinical trials for myelofibrosis and lymphoma
    Lee, Angeline
    William, Anthony
    Poulsen, Anders
    Tan, Evelyn
    Nagaraj, Harish
    Goh, Kay Lin
    Ong, Wai Chung
    Goh, Kee Chuan
    Pasha, Mohammed Khalid
    Jayaraman, Ramesh
    Ethirajulu, Kantharaj
    Wood, Jeanette M.
    Dymock, Brian W.
    CANCER RESEARCH, 2011, 71
  • [8] SB1518: A potent and orally active JAK2 inhibitor for the treatment of myeloproliferative disorders.
    Goh, Kee C.
    Ong, Wai C.
    Hu, Changyong
    Hentze, Harries
    Liang, Ai L.
    Stunkel, Walter
    Tan, Yong C.
    Sangthongpitag, Kanda
    Goh, Siok K.
    Sieh, Shirly
    Bonday, Zahid Q.
    William, Anthony D.
    Lee, Angeline
    Llanchard, Stephanie
    Liu, Te C.
    Sattler, Martin
    Griffin, James D.
    Dymock, Brian W.
    Kantharaj, Ethirajulu
    Wood, Jeanette M.
    BLOOD, 2007, 110 (11) : 165A - 166A
  • [9] Phase II study of SB1518, an orally available novel JAK2 inhibitor, in patients with myelofibrosis
    Deeg, H. J.
    Odenike, O.
    Scott, B. L.
    Estrov, Z.
    Cortes, J. E.
    Thomas, D. A.
    Zhu, H. J.
    Kantarjian, H.
    Verstovsek, S.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
  • [10] Phase I Dose-Escalation Trial of SB1518, a Novel JAK2/FLT3 Inhibitor, in Acute and Chronic Myeloid Diseases, Including Primary or Post-Essential Thrombocythemia Polycythemia Vera Myelofibrosis
    Verstovsek, Srdan
    Odenike, Olatoyosi
    Scott, Bart
    Estrov, Zeev
    Cortes, Jorge
    Thomas, Deborah A.
    Wood, Jeanette
    Ethirajulu, Kantharaj
    Lowe, Ann
    Zhu, Huan J.
    Kantarjian, Hagop
    Deeg, H. Joachim
    BLOOD, 2009, 114 (22) : 1502 - 1502