Antiviral effects of human milk oligosaccharides: A review

被引:17
|
作者
Gao, Xiaoxiang [1 ]
Wu, Desheng [1 ]
Wen, Yuxi [1 ,2 ,3 ]
Gao, Luying [4 ]
Liu, Dan [1 ]
Zhong, Ruting [1 ]
Yang, Chengfeng [5 ]
Zhao, Chao [1 ,2 ,3 ]
机构
[1] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
[2] Fujian Agr & Forestry Univ, Inst Oceanol, Key Lab Marine Biotechnol Fujian Prov, Fuzhou 350002, Peoples R China
[3] Quanzhou Normal Univ, Fujian Prov Key Lab Dev Bioact Mat Marine Algae, Quanzhou 362000, Peoples R China
[4] Nanjing Med Univ, Nanjing Hosp 1, Dept Pediat, Nanjing 210006, Peoples R China
[5] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
关键词
BLOOD GROUP ANTIGENS; BINDS DC-SIGN; INFLUENZA-VIRUS; ENTEROVIRUS; 71; NOROVIRUS INHIBITION; ROTAVIRUS VACCINE; STRUCTURAL BASIS; INFECTION; HIV-1; RECEPTORS;
D O I
10.1016/j.idairyj.2020.104784
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Virus infections can threaten human life and health and often cause considerable losses to society. There are multiple ways for viruses to invade host cells. Therefore, it is immensely important to inhibit the contact between virus and host cell receptors. Human milk oligosaccharides (HMOs) can not only benefit the infant brain development and the immune system enhancement, but also prevent cells from virus infections due to their similar structures with viral receptors, such as histo-blood group antigens, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin, and sialic acid receptors. In this review, we outline the current knowledge on the complex structures of HMOs and the characteristics of infection by viruses, as well as discuss the mechanisms by which HMOs protect cells against various virus invasions. (C) 2020 Elsevier Ltd. All rights reserved.
引用
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页数:10
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