miRNA profiling for biomarker discovery in multiple sclerosis: From microarray to deep sequencing

被引：66
|
作者：
Guerau-de-Arellano, Mireia [1 ,2 ]
Alder, Hansjuerg [3 ]
Ozer, Hatice Gulcin [4 ]
Lovett-Racke, Amy [3 ]
Racke, Michael K. [1 ]
机构：
[1] Ohio State Univ, Med Ctr, Dept Neurol, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA
[3] Ohio State Univ, Med Ctr, Mol Virol Immunol & Med Genet Dept, Columbus, OH 43210 USA
[4] Ohio State Univ, Med Ctr, Ctr Comprehens Canc, Columbus, OH 43210 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 248卷 / 1-2期
关键词：
miRNA; Profiling; Biomarker; Multiple sclerosis; Neuroimmunology; Autoimmunity; MYELIN BASIC-PROTEIN; MICRORNA GENES; C-ELEGANS; RNA-INTERFERENCE; T-CELLS; EXPRESSION; DIFFERENTIATION; AUTOIMMUNITY; BIOGENESIS; TARGETS;
D O I：
10.1016/j.jneuroim.2011.10.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. miRNAs are highly expressed in cells of the immune and nervous system, attesting to their importance in Neuroimmunology. Besides their involvement in modulation of physiological and pathological processes, miRNAs hold high promise as disease biomarkers, therapeutic agents and/or drug targets. Several studies have recently explored the involvement of miRNAs in Multiple Sclerosis (MS) using a variety of miRNA profiling techniques. In this review, we discuss basic miRNA biology and nomenclature, the techniques available for miRNA profiling research and recent miRNA profiling studies in Multiple Sclerosis. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：32 / 39
页数：8
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