Pseudo-observations for competing risks with covariate dependent censoring

被引:52
|
作者
Binder, Nadine [1 ]
Gerds, Thomas A. [2 ]
Andersen, Per Kragh [2 ]
机构
[1] Univ Med Ctr Freiburg, Inst Med Biometry & Med Informat, D-79104 Freiburg, Germany
[2] Univ Copenhagen, Dept Biostat, DK-1014 Copenhagen K, Denmark
关键词
Competing risks; Covariate-dependent censoring; Cumulative incidence; Pseudo-observations; REGRESSION; MODELS;
D O I
10.1007/s10985-013-9247-7
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
Regression analysis for competing risks data can be based on generalized estimating equations. For the case with right censored data, pseudo-values were proposed to solve the estimating equations. In this article we investigate robustness of the pseudo-values against violation of the assumption that the probability of not being lost to follow-up (un-censored) is independent of the covariates. Modified pseudo-values are proposed which rely on a correctly specified regression model for the censoring times. Bias and efficiency of these methods are compared in a simulation study. Further illustration of the differences is obtained in an application to bone marrow transplantation data and a corresponding sensitivity analysis.
引用
收藏
页码:303 / 315
页数:13
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