Borf-1 protein identified as a transcriptional trans-activator of bovine foamy virus

被引：7
|
作者：
Liu, JJ [1 ]
Liu, SH [1 ]
Chen, QM [1 ]
Geng, YQ [1 ]
机构：
[1] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China
来源：
CHINESE SCIENCE BULLETIN | 1999年 / 44卷 / 11期
关键词：
bovine foamy virus (BFV)3026 China Strain; transcriptional trans-activator; transient expression assay;
D O I：
10.1007/BF02886021
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Bovine foamy virus (BFV), a member of the spumavirus subfamily of retroviruses, contains two open reading frames (ORF-1 and ORF-2) in addition to the genes coding for gag, pol and env. Borf-1 protein, encoded by BFV ORF-1, is identified as a transcriptional trans-activator, which augments gene expression directed by the viral long terminal repeat (LTR). Further investigations in transient expression assays reveal that the Borf-1 responsive elements are located in the U3 domain of the LTR, upstream from position -140 (+1 represents the transcription initiation site), and the BFV RU5 region has an inhibitory effect in LTR-directed gene expression.
引用
收藏
页码：1017 / 1021
页数：5
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