Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

被引：45
|
作者：
Puri, Vivek [1 ,2 ]
Sharma, Ameya [1 ,2 ]
Kumar, Pradeep [3 ]
Singh, Inderbir [1 ]
机构：
[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India
[2] Chitkara Univ, Sch Pharm, Solan 174103, Himachal Prades, India
[3] Univ Witwatersrand, Sch Therapeut Sci, Dept Pharm & Pharmacol, Fac Hlth Sci, ZA-2193 Johannesburg, South Africa
来源：
POLYMERS | 2020年 / 12卷 / 08期
关键词：
thiolation; biopolymers; drug delivery systems; mechanical properties; mucoadhesive properties; patents; IN-VITRO EVALUATION; CHITOSAN NANOPARTICLES; VISCOELASTIC PROPERTIES; GEL FORMULATIONS; HYALURONIC-ACID; ORAL DELIVERY; CROSS-LINKING; POLYMERS; FILMS; PECTIN;
D O I：
10.3390/polym12081803
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail. Reported literature on thiolated biopolymers with enhanced mechanical and mucoadhesive properties has been presented conspicuously in text as well as in tabular form. Patents filed by researchers on thiolated polymers have also been presented. In conclusion, thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications.
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收藏
页数：27
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