An efficient synthesis of orthogonally protected spermidine

被引：6

作者：

Amssoms, K ^{[1
]}

Augustyns, K ^{[1
]}

Yamani, A ^{[1
]}

Zhang, M ^{[1
]}

Haemers, A ^{[1
]}

机构：

[1] Univ Instelling Antwerp, B-2610 Wilrijk, Belgium

来源：

SYNTHETIC COMMUNICATIONS | 2002年 / 32卷 / 03期

关键词：

D O I：

10.1081/SCC-120002114

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A major problem in the use of spermidine for the synthesis of biologically interesting compounds is the selective orthogonal protection of the three different amino groups. Our approach is based on the Fukuyama reaction, starting from putrescine and 3-amino-1-propanol and affording N-8-benzyloxycarbonyl-N-1-tert-butyloxycarbonyl-N-4-(2-nitro-benzenesulfonyl)spermidine (5) in 5 steps in high yield.

引用

页码：319 / 328

页数：10

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