Severe Chronic Allergic (and Related) Diseases: A Uniform Approach - A MeDALL - GA2LEN - ARIA Position Paper

被引：78

作者：

Bousquet, J. ^{[1
,2
,6
]}

Anto, J. M. ^{[3
,4
,5
]}

Demoly, P. ^{[6
,7
]}

Schuenemann, H. J. ^{[8
]}

Togias, A. ^{[9
]}

Akdis, M. ^{[10
]}

Auffray, C. ^{[11
]}

Bachert, C. ^{[12
]}

Bieber, T. ^{[13
]}

Bousquet, P. J. ^{[1
,6
]}

Carlsen, K. H. ^{[14
]}

Casale, T. B. ^{[15
]}

Cruz, A. A. ^{[16
]}

Keil, T. ^{[17
]}

Carlsen, K. C. Lodrup ^{[14
]}

Maurer, M. ^{[18
]}

Ohta, K. ^{[19
]}

Papadopoulos, N. G. ^{[20
]}

Rodriguez, M. Roman ^{[21
]}

Samolinski, B. ^{[22
]}

Agache, I. ^{[23
]}

Andrianarisoa, A. ^{[24
]}

Ang, C. S. ^{[38
]}

Annesi-Maesano, I. ^{[25
,26
]}

Ballester, F. ^{[27
,28
]}

Baena-Cagnani, C. E. ^{[29
,30
]}

Basagana, X. ^{[3
,4
]}

Bateman, E. D. ^{[31
]}

Bel, E. H. ^{[32
]}

Bedbrook, A. ^{[6
]}

Beghe, B. ^{[33
,34
]}

Beji, M. ^{[35
]}

Ben Kheder, A. ^{[36
]}

Benet, M. ^{[3
,4
]}

Bennoor, K. S. ^{[37
]}

Bergmann, K. C. ^{[18
]}

Berrissoul, F. ^{[38
]}

Jensen, C. Bindslev ^{[39
]}

Bleecker, E. R. ^{[40
]}

Bonini, S. ^{[41
,42
]}

Boner, A. L. ^{[43
]}

Boulet, L. P. ^{[44
,45
]}

Brightling, C. E. ^{[46
]}

Brozek, J. L. ^{[8
]}

Bush, A. ^{[47
,48
]}

Busse, W. W. ^{[49
]}

Camargos, P. A. M. ^{[50
]}

Canonica, G. W. ^{[51
]}

Carr, W. ^{[52
]}

Cesario, A. ^{[53
,54
]}

机构：

[1] Hop Arnaud de Villeneuve, Dept Resp Dis, Univ Hosp, Montpellier, France

[2] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, U1018, Resp & Environm Epidemiol Team, Villejuif, France

[3] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[4] IMIM Hosp Mar, Municipal Inst Med Res, Barcelona, Spain

[5] UPF, Barcelona, Spain

[6] WHO Collaborating Ctr Asthma & Rhinitis, Montpellier, France

[7] Hop Arnaud de Villeneuve, INSERM, U657, Univ Hosp Montpellier, Montpellier, France

[8] McMaster Univ, Dept Clin Epidemiol & Biostat & Med, Hamilton, ON, Canada

[9] NIAID, Bethesda, MD 20892 USA

[10] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[11] CNRS Inst Biol Sci, Villejuif, France

[12] Univ Hosp Ghent, URL Upper Airways Res Lab, Ghent, Belgium

[13] Univ Med Ctr, Dept Dermatol & Allergy, Bonn, Germany

[14] Univ Oslo, Oslo Univ Hosp, Dept Paediat, Oslo, Norway

[15] Creighton Univ, Dept Med, Div Allergy & Immunol, Omaha, NE 68178 USA

[16] Univ Fed Bahia, Sch Med, ProAR FMB, Salvador, BA, Brazil

[17] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany

[18] Charite, Allergy Ctr Charite, Dept Dermatol, D-13353 Berlin, Germany

[19] Teikyo Univ, Sch Med, Dept Med, Div Resp Med & Allergol, Tokyo 173, Japan

[20] Univ Athens, Dept Allergy, Pediat Clin 2, Athens, Greece

[21] Son Pisa Primary Care Ctr, IB Salut Balear Hlth Serv, Palma de Mallorca, Spain

[22] Med Univ Warsaw, Dept Prevent Environm Hazards & Allergol, Warsaw, Poland

[23] Transylvania Univ, Fac Med, Brasov, Romania

[24] Minist Hlth, Publ Hosp Med Serv, Antananarivo, Madagascar

[25] INSERM, EPAR U707, Paris, France

[26] EPAR UMR S UPMC, Paris, France

[27] Univ Valencia, Valencia, Spain

[28] Ctr Publ Hlth Res CSISP, Valencia, Spain

[29] Catholic Univ, Fac Med, Cordoba, Argentina

[30] Univ Genoa, Sch Specializat, Genoa, Italy

[31] Univ Cape Town, Fac Hlth Sci, ZA-7925 Cape Town, South Africa

[32] Univ Amsterdam, Acad Med Ctr, Dept Pulmonol, NL-1012 WX Amsterdam, Netherlands

[33] Univ Southampton, Div Human Genet Infect, Sch Med, Southampton, Hants, England

[34] Univ Southampton, Div Human Genet Infect Inflammat & Repair, Sch Med, Southampton, Hants, England

[35] Ctr Hositalo Univ Rabta, Serv Pneumol Allergol, Tunis, Tunisia

[36] Hop A Mami, Ariana, Tunisia

[37] Natl Inst Dis Chest & Hosp, Dhaka, Bangladesh

[38] Natl Inst Dis Chest & Hosp, Air Khmer, Cambodia

[39] Odense Univ Hosp, DK-5000 Odense, Denmark

[40] Wake Forest Univ Hlth Sci, Winston Salem, NC USA

[41] Inst Neurobiol & Mol Med CNR, Rome, Italy

[42] Univ Naples 2, Dept Med, Naples, Italy

[43] Univ Verona, Dept Paediat, I-37100 Verona, Italy

[44] Hop Laval, Inst Cardiol & Pneumol, Quebec City, PQ, Canada

[45] Univ Laval, Quebec City, PQ, Canada

[46] Inst Lung Hlth, Leicester, Leics, England

[47] Royal Brompton Hosp, Dept Paediat Resp Med, London SW3 6LY, England

[48] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England

[49] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI USA

[50] Univ Fed Minas Gerais, Sch Med, Dept Pediat, Belo Horizonte, MG, Brazil

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2012年 / 158卷 / 03期

关键词：

Immunoglobulin E; Asthma; Rhinitis; Rhinosinusitis; Urticaria; Atopic dermatitis; IMPORTANT RESEARCH QUESTIONS; WORLD-HEALTH-ORGANIZATION; QUALITY-OF-LIFE; ATOPIC-DERMATITIS; SEVERE ASTHMA; CHRONIC RHINOSINUSITIS; NASAL POLYPOSIS; NONALLERGIC RHINITIS; CLUSTER-ANALYSIS; ECZEMA AREA;

D O I：

10.1159/000332924

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：216 / 231

页数：16

共 25 条

[21] Towards a common approach for managing food allergy and serious allergic reactions (anaphylaxis) at school. GA2LEN and EFA consensus statement
Deschildre, Antoine
Alvaro-Lozano, Montserrat
Muraro, Antonella
Podesta, Marcia
de Silva, Debra
Giovannini, Mattia
Barni, Simona
Dribin, Timothy E.
Sandoval-Ruballos, Monica
Anagnostou, Aikaterini
Fiocchi, Alessandro
Toniolo, Alice
Bird, Andrew
Sanchez Sanz, Angel
Asarnoj, Anna
Nowak-Wegrzyn, Anna
Vlieg-Boerstra, Berber
Vickery, Brian P.
Venter, Carina
Nilsson, Caroline
Parente, Cecilia
Demoulin, Celine
Fleischer, David M.
Bijlhout, Diola
Knol, Edward F.
Garrow, Eleanor
Cook, Emma E.
Schultz, Fallon
Lazzarotto, Francesca
Mori, Francesca
Wong, Gary
Lack, Gideon
Roberts, Graham
Andres Marino, Gustavo
Elberink, H. N. G. Oude
Brough, Helen A.
Sampson, Hugh A.
Lieberman, Jay
Gerdts, Jennifer
Zhao, Jing
Gradman, Josefine
Upton, Julia E. M.
Wang, Julie
Palosuo, Kati
Jarvinen, Kirsi M.
Beyer, Kirsten
Shen, Kunling
Polloni, Laura
Mandelbaum, Lianne
Tanno, Luciana Kase
CLINICAL AND TRANSLATIONAL ALLERGY, 2025, 15 (01)
[22] Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA2LEN position paper
Zuberbier, Torsten
Doerr, Tamara
Aberer, Werner
Alvaro, Montserrat
Angier, Elizabeth
Arasi, Stefania
Arshad, Hasan
Ballmer-Weber, Barbara
Bartra, Joan
Beck, Lisa
Begin, Philippe
Bindslev-Jensen, Carsten
Bislimovska, Jovanka
Bousquet, Jean
Brockow, Knut
Bush, Andrew
Cianferoni, Antonella
Cork, Michael J.
Custovic, Adnan
Darsow, Ulf
Jong, Nicolette
Deleanu, Diana
Del Giacco, Stefano
Deschildre, Antoine
Galvin, Audrey Dunn
Ebisawa, Motohiro
Fernandez-Rivas, Montserrat
Ferrer, Marta
Fiocchi, Alessandro
van Wijk, Roy Gerth
Gotua, Maia
Grimshaw, Kate
Gruenhagen, Josefine
Heffler, Enrico
Hide, Michihiro
Hoffmann-Sommergruber, Karin
Incorvaia, Cristoforo
Janson, Christer
John, Swen Malte
Jones, Carla
Jutel, Marek
Katoh, Norito
Kendziora, Benjamin
Kinaciyan, Tamar
Knol, Edward
Kurbacheva, Oksana
Lau, Susanne
Loh, Richard
Lombardi, Carlo
Makela, Mika
ALLERGY, 2022, 77 (06) : 1736 - 1750
[23] Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA2LEN)
F. Braido
N. Scichilone
F. Lavorini
O. S. Usmani
L. Dubuske
L. P. Boulet
R. Mosges
C. Nunes
M. Sánchez-Borges
I. J. Ansotegui
M. Ebisawa
F. Levi-Schaffer
L. J Rosenwasser
J. Bousquet
T. Zuberbier
G. Walter Canonica
Asthma Research and Practice, 2 (1)
[24] Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA2LEN)
Braido, F.
Scichilone, N.
Lavorini, F.
Usmani, O. S.
Dubuske, L.
Boulet, L. P.
Mosges, R.
Nunes, C.
Sanchez-Borges, M.
Ansotegui, I. J.
Ebisawa, M.
Levi-Schaffer, F.
Rosenwasser, L. J.
Bousquet, J.
Zuberbier, T.
Canonica, G. Walter
WORLD ALLERGY ORGANIZATION JOURNAL, 2016, 9 : 1 - 6
[25] Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA2LEN) (pg 9, 2016)
Canonica, G. Walter
WORLD ALLERGY ORGANIZATION JOURNAL, 2022, 15 (02):

← 1 2 3 →