An introduction for the special issue on environmental health and genome integrity

被引：1

作者：

Yan, Shan ^{[1
]}

Vaziri, Cyrus ^{[2
]}

机构：

[1] Univ N Carolina, Dept Biol Sci, Charlotte, NC 28223 USA

[2] Univ N Carolina, Sch Med, Dept Pathol & Lab Med, Chapel Hill, NC 27515 USA

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2020年 / 61卷 / 07期

关键词：

DNA damage response; DNA repair; genome intergrity; DNA-DAMAGE RESPONSE; REPAIR; ATR; PATHWAYS;

D O I：

10.1002/em.22400

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Environmental exposures and genome maintenance mechanisms that respond to environmentally-induced genotoxicity have a profound impact on human health. Eight review articles in this Special Issue (SI) titled "Environmental Health and Genome Integrity" describe emerging new mechanisms by which distinct forms of environmentally-induced DNA damage are remediated, and explain how DNA repair pathway choices impact genome integrity and disease propensity. Here, we provide an introduction to reviews from this SI. Our expanding knowledge of how genotoxic exposures impact the genome will allow us to better predict, prevent and treat environmentally-induced human diseases such as cancer and neurodegenerative disorders.

引用

页码：660 / 663

页数：4

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